Pulmonary Langerhans cell histiocystosis (PLCH) and lymphangioleiomyomatosis (LAM) have circulating cells with loss of heterozygosity of the TSC2 gene.
Sign Up to like & getrecommendations! Published in 2022 at "Chest"
DOI: 10.1016/j.chest.2022.02.032
Abstract: BACKGROUND Lymphangioleiomyomatosis (LAM) and pulmonary Langerhans Cell Histiocytosis (PLCH) are cystic lung diseases in which a neoplastic cell is believed to be responsible for disease pathogenesis. The neoplastic LAM cell has mutations in the Tuberous… read more here.
Keywords: tsc2 loh; cell; lymphangioleiomyomatosis lam; plch ... See more keywords
Current understanding and management of pulmonary Langerhans cell histiocytosis
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DOI: 10.1136/thoraxjnl-2017-210125
Abstract: Pulmonary Langerhans cell histiocytosis (PLCH) is a diffuse lung disease that usually affects young adult smokers. PLCH affects different lung compartments; bronchiolar, interstitial and pulmonary vascular dysfunction may coexist to varying extents, resulting in diverse… read more here.
Keywords: langerhans cell; plch; disease; cell histiocytosis ... See more keywords
Pulmonary Langerhans cell histiocytosis and multiple system involvement: A case report
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DOI: 10.12998/wjcc.v9.i35.11029
Abstract: BACKGROUND Pulmonary Langerhans cell histiocytosis (PLCH) is a relatively rare type of lung disease, common in middle-aged smoking men. It is characterized by proliferation and infiltration of Langerhans cells, and the formation of multiple parabronchial… read more here.
Keywords: cell histiocytosis; diagnosis; langerhans cell; plch ... See more keywords
Cross-Resistance between Platinum-Based Chemotherapy and PARP Inhibitors in Castration-Resistant Prostate Cancer
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DOI: 10.3390/cancers15102814
Abstract: Simple Summary Platinum-based chemotherapy and PARP inhibitors are two types of treatment that can benefit prostate cancer patients with mutations in genes that are involved in the repair of damage in the DNA. However, patients… read more here.
Keywords: prostate cancer; plch; treatment; platinum based ... See more keywords
Bronchoalveolar Lavage as a Diagnostic Tool in an Atypical Pulmonary Langerhans Cell Histiocytosis
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DOI: 10.3390/diagnostics12061394
Abstract: Pulmonary Langerhans cell histiocytosis (PLCH) is an uncommon diffuse cystic lung disease that occurs almost exclusively in young adult smokers. High-resolution computed tomography of the chest allows a confident diagnosis of PLCH in typical presentation,… read more here.
Keywords: langerhans cell; bronchoalveolar lavage; cell histiocytosis; pulmonary langerhans ... See more keywords
Clinical Research of Pulmonary Langerhans Cell Histiocytosis in Children
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DOI: 10.4103/0366-6999.237400
Abstract: Background: Pulmonary Langerhans cell histiocytosis (PLCH) is an interstitial primary pulmonary disease, characterized by Langerhans cell proliferation. It is easily misdiagnosed in children. This study aimed to characterize the clinical manifestations and features of PLCH… read more here.
Keywords: langerhans cell; plch children; organ involvement; plch ... See more keywords
Pulmonary Langerhans' cell histiocytosis in adults.
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DOI: 10.5603/arm.a2017.0046
Abstract: Pulmonary Langerhans' cell histiocytosis (PLCH) is a rare disorder of unknown cause characterised by the infiltration of the lungs and other organs by the bone marrow derived Langerhans' cells, which carry mutations of BRAF gene… read more here.
Keywords: langerhans cell; plch; cell histiocytosis; pulmonary langerhans ... See more keywords