Aflatoxin B1 induces S phase arrest by upregulating the expression of p21 via MYC, PLK1 and PLD1.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.05.008
Abstract: Aflatoxin B1 (AFB1), a member of the aflatoxin family, is a common contaminant in foods and feeds, and AFB1 exposure is associated with various clinical conditions. Thus far, research on the toxicity of AFB1 has… read more here.
Keywords: plk1; pld1; p21; phase arrest ... See more keywords
PLD1 promotes tumor invasion by regulation of MMP-13 expression via NF-κB signaling in bladder cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.04.014
Abstract: Invasion of bladder cancer (BC) cells from the mucosa into the muscle layer is canonical for BC progression while phospholipase D isoform 1 (PLD1) is known to mediate development of cancer through phosphatidic acid (PA)… read more here.
Keywords: invasion; mmp expression; pld1; tumor invasion ... See more keywords
PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06121-2
Abstract: Synapses are the basic units of information transmission, processing and integration in the nervous system. Dysfunction of the synaptic development has been recognized as one of the main reasons for mental dementia and psychiatric diseases… read more here.
Keywords: cleavage; pld1 promotes; pld1; promotes dendritic ... See more keywords
Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09996-3
Abstract: Amyloid β (Aβ) accumulation is an early event in the pathogenesis of Alzheimer’s disease (AD), leading to mitochondrial and synaptic dysfunction, tau accumulation, and eventual neuronal death. While the p53 apoptotic pathway has clearly been… read more here.
Keywords: neuronal apoptosis; pld1; translocation; cofilin ... See more keywords
Next Generation Sequencing in a Case of Early Onset Hydrops: Closing the Loop on the Diagnostic Odyssey!
Sign Up to like & getrecommendations! Published in 2022 at "Fetal and Pediatric Pathology"
DOI: 10.1080/15513815.2022.2058660
Abstract: Abstract Background: Non-immune fetal hydrops (NIFH) is an etiologically heterogeneous condition. Cardiac anomalies are one of the common causes of NIFH. Cardiac anomalies can be isolated, multifactorial malformations or have a genetic basis. PLD1 variants… read more here.
Keywords: right heart; case; next generation; pld1 ... See more keywords
Inhibition of phospholipase D1 reduces pancreatic carcinogenesis in mice partly through a FAK-dependent mechanism.
Sign Up to like & getrecommendations! Published in 2024 at "Carcinogenesis"
DOI: 10.1093/carcin/bgae071
Abstract: Phospholipase D (PLD) plays a critical role in cancer progression. However, its role in pancreatic cancer remains unclear. Thus, we evaluated the role of PLD1, one of two classical isoforms of PLD, in pancreatic carcinogenesis… read more here.
Keywords: mice; role; pld1; pancreatic carcinogenesis ... See more keywords
Phospholipase D1 promotes cervical cancer progression by activating the RAS pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17439
Abstract: This study aimed to further investigate the effect of PLD1 on the biological characteristics of human cervical cancer (CC) cell line, CASKI and the potential related molecular mechanism. CRISPR/Cas9 genome editing technology was used to… read more here.
Keywords: caski cells; cervical cancer; activating ras; ras pathway ... See more keywords
Abstract 3356: Inhibiting phospholipase D1 reduces pancreatic carcinogenesis in mice
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3356
Abstract: New therapeutic targets are needed for pancreatic ductal adenocarcinoma (PDAC), a leading cause of cancer-related death worldwide. Phospholipase D (PLD) is a lipid-signaling enzyme that appears to play a critical role in cell proliferation, survival/apoptosis,… read more here.
Keywords: mice; cancer; pld1 mice; pld1 ... See more keywords