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   Articles with "pld2" as a keyword



Phospholipase D2 Regulates Microtubule Acetylation by Modulating Gsk3β‐Tau Signaling in Mouse Oocytes During Meiotic Maturation

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recommendations! Published in 2025 at "Molecular Reproduction and Development"

DOI: 10.1002/mrd.70051

Abstract: Phospholipase D2 (PLD2) modulates cytoskeletal dynamics and membrane trafficking processes by converting phosphatidylcholine (PC) into phosphatidic acid (PA) and choline within somatic cells. Nonetheless, the role in oocyte meiosis remains largely unknown. Here, we demonstrate… read more here.

Keywords: pld2; tau; gsk3 tau; mouse oocytes ... See more keywords

PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway

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recommendations! Published in 2024 at "Inflammation Research"

DOI: 10.1007/s00011-024-01881-w

Abstract: Sepsis-induced cardiomyopathy (SICM) is a life-threatening complication. Phospholipase D2 (PLD2) is crucial in mediating inflammatory reactions and is associated with the prognosis of patients with sepsis. Whether PLD2 is involved in the pathophysiology of SICM… read more here.

Keywords: pyroptosis; pld2; caspase gsdmd; pld2 deletion ... See more keywords

Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.

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recommendations! Published in 2017 at "Developmental cell"

DOI: 10.1016/j.devcel.2017.09.012

Abstract: Little is known about the cellular events promoting metastasis. We show that knockout of phospholipase D2 (PLD2), which generates the signaling lipid phosphatidic acid (PA), inhibits lung metastases in the mammary tumor virus (MMTV)-Neu transgenic… read more here.

Keywords: mt1 mmp; pld2; breast cancer; metastasis ... See more keywords

Upregulated phospholipase D2 expression and activity is related to the metastatic properties of melanoma

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recommendations! Published in 2022 at "Oncology Letters"

DOI: 10.3892/ol.2022.13260

Abstract: The incidence rates of melanoma have increased steadily in recent decades and nearly 25% of the patients diagnosed with early-stage melanoma will eventually develop metastasis, for which there is currently no fully effective treatment. The… read more here.

Keywords: melanoma; pld2; expression; activity ... See more keywords