Modes of Interaction of Pleckstrin Homology Domains with Membranes: Toward a Computational Biochemistry of Membrane Recognition.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.12.011
Abstract: Pleckstrin homology (PH) domains mediate protein-membrane interactions by binding to phosphatidylinositol phosphate (PIP) molecules. The structural and energetic basis of selective PH-PIP interactions is central to understanding many cellular processes, yet the molecular complexities of… read more here.
Keywords: biochemistry; homology domains; pleckstrin homology; membrane recognition ... See more keywords
Pleckstrin homology-like domain family A, member 3, a miR-19a-3p-regulated gene, suppresses tumor growth in osteosarcoma by downregulating the Akt pathway
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DOI: 10.1080/21655979.2022.2031404
Abstract: ABSTRACT Pleckstrin homology-like domain family A, member 3 (PHLDA3), is emerging as a critical regulator for multiple cancers. Nevertheless, the expression and role of PHLDA3 in osteosarcoma remain unknown. Herein, we purposed to elucidate the… read more here.
Keywords: homology like; osteosarcoma; mir 19a; pleckstrin homology ... See more keywords
Regulation of AKT activity by inhibition of the pleckstrin homology domain-PtdIns(3,4,5)P3 interaction using flavonoids.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1805.04051
Abstract: The serine-threonine kinase AKT plays a pivotal role in tumor progression and is frequently overactivated in cancer cells; this protein is therefore a critical therapeutic target for cancer intervention. We aimed to identify small molecule… read more here.
Keywords: akt; pleckstrin homology; inhibition; homology domain ... See more keywords