Plectin Mutations in Progressive Familial Intrahepatic Cholestasis
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30841
Abstract: Neonates and infants are susceptible to cholestatic liver diseases. At least six genes are causative for progressive familial intrahepatic cholestasis (PFIC), and more genetic defects are known to cause infant cholestasis.(1) Approximately one-third of PFIC… read more here.
Keywords: familial intrahepatic; plec; progressive familial; intrahepatic cholestasis ... See more keywords
Loss of interaction between plectin and type XVII collagen results in epidermolysis bullosa simplex
Sign Up to like & getrecommendations! Published in 2017 at "Human Mutation"
DOI: 10.1002/humu.23344
Abstract: Plectin is a linker protein that interacts with intermediate filaments and β4 integrin in hemidesmosomes of the epidermal basement membrane zone (BMZ). Type XVII collagen (COL17) has been suggested as another candidate plectin binding partner… read more here.
Keywords: plectin col17; xvii collagen; type xvii; plectin ... See more keywords
Plectin ensures intestinal epithelial integrity and protects colon against colitis
Sign Up to like & getrecommendations! Published in 2021 at "Mucosal Immunology"
DOI: 10.1038/s41385-021-00380-z
Abstract: Plectin, a highly versatile cytolinker protein, provides tissues with mechanical stability through the integration of intermediate filaments (IFs) with cell junctions. Here, we hypothesize that plectin-controlled cytoarchitecture is a critical determinant of the intestinal barrier… read more here.
Keywords: ensures intestinal; intestinal epithelial; plectin ensures; colon ... See more keywords
Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memory
Sign Up to like & getrecommendations! Published in 2020 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12635
Abstract: Plectin, a universally expressed multi‐functional cytolinker protein, is crucial for intermediate filament networking, including crosstalk with actomyosin and microtubules. In addition to its involvement in a number of diseases affecting skin, skeletal muscle, heart, and… read more here.
Keywords: plectin dysfunction; tau accumulation; leads tau; plectin ... See more keywords
[99mTc]Tc-Labeled Plectin-Targeting Peptide as a Novel SPECT Probe for Tumor Imaging
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DOI: 10.3390/pharmaceutics14050996
Abstract: Certain receptors are often overexpressed during tumor occurrence and development and closely correlate with carcinogenesis. Owing to its overexpression on the cell membrane and cytoplasm of various tumors, plectin, which is involved in tumor proliferation,… read more here.
Keywords: tumor imaging; spect probe; 99mtc labeled; plectin ... See more keywords
Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer
Sign Up to like & getrecommendations! Published in 2018 at "Theranostics"
DOI: 10.7150/thno.23050
Abstract: Advances in genomics and proteomics drive precision medicine by providing actionable genetic alterations and molecularly targeted therapies, respectively. While genomic analysis and medicinal chemistry have advanced patient stratification with treatments tailored to the genetic profile… read more here.
Keywords: parp inhibitor; ovarian cancer; plectin; cancer ... See more keywords