Enhanced Identification of Potential Pleiotropic Genetic Variants for Bone Mineral Density and Breast Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Calcified Tissue International"
DOI: 10.1007/s00223-017-0308-x
Abstract: Epidemiological and clinical evidences have shown that bone mineral density (BMD) has a close relationship with breast cancer (BC). They might potentially have a shared genetic basis. By incorporating information about these pleiotropic effects, we… read more here.
Keywords: bone mineral; pleiotropic genetic; breast cancer; potential pleiotropic ... See more keywords
A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density
Sign Up to like & getrecommendations! Published in 2021 at "Cell Metabolism"
DOI: 10.1016/j.cmet.2021.01.001
Abstract: Summary Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may have pleiotropic effects, we studied Genome-wide association studies (GWASs) for bone mineral density… read more here.
Keywords: bone mineral; risk; regulatory variant; mineral density ... See more keywords
P.3.003 Pleiotropic genes in psychiatry: calcium channels and the stress-related FKBP5 gene in antidepressant resistance
Sign Up to like & getrecommendations! Published in 2018 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.12.093
Abstract: Background Major depressive disorder is a high-prevalence disease associated with a heavy burden on both personal well-being and socio-economical welfare, partly as a result of lacking tailored treatment options [1]. Common single nucleotide polymorphisms (SNPs)… read more here.
Keywords: response; trd; remission; association ... See more keywords
Pleiotropic activity of systemically delivered angiogenin in the SOD1G93A mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.02.022
Abstract: ABSTRACT Loss‐of‐function mutations in the angiogenin (ANG) gene have been identified in familial and sporadic ALS patients. Previous work from our group identified human ANG (huANG) to protect motoneurons in vitro, and provided proof‐of‐concept that… read more here.
Keywords: sod1g93a; huang; treatment; pleiotropic ... See more keywords
Pleiotropic Immunomodulatory Functions of Radioactive Inactivated Bacterial Vectors for Enhanced Cancer Radio-immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c04982
Abstract: Biomaterial-based pleiotropic immune activation may effectively improve the response rate of immunotherapy and enhance the therapeutic effect of the tumor. Bacteria as a natural carrier have demonstrated great advantages in tumor targeted delivery and immune… read more here.
Keywords: pleiotropic; immunotherapy; bacterial vectors; radio immunotherapy ... See more keywords
LECT2: A pleiotropic and promising hepatokine, from bench to bedside
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17407
Abstract: LECT2 (leucocyte cell‐derived chemotaxin 2) is a 16‐kDa protein mainly produced by hepatocytes. It was first isolated in PHA‐activated human T‐cell leukaemia SKW‐3 cells and originally identified as a novel neutrophil chemotactic factor. However, many… read more here.
Keywords: promising hepatokine; pleiotropic promising; bench bedside; pleiotropic ... See more keywords
Comprehensive identification of pleiotropic loci for body fat distribution using the NHGRI‐EBI Catalog of published genome‐wide association studies
Sign Up to like & getrecommendations! Published in 2019 at "Obesity Reviews"
DOI: 10.1111/obr.12806
Abstract: We conducted a hypothesis‐free cross‐trait analysis for waist‐to‐hip ratio adjusted for body mass index (WHRadjBMI) loci derived through genome‐wide association studies (GWAS). Summary statistics from published GWAS were used to capture all WHRadjBMI single‐nucleotide polymorphisms… read more here.
Keywords: genome wide; cross trait; snps; association ... See more keywords
Potential Pleiotropic Genes and Shared Biological Pathways in Epilepsy and Depression Based on GWAS Summary Statistics
Sign Up to like & getrecommendations! Published in 2022 at "Computational Intelligence and Neuroscience"
DOI: 10.1155/2022/6799285
Abstract: Current epidemiological and experimental studies have indicated the overlapping genetic foundation of epilepsy and depression. However, the detailed pleiotropic genetic etiology and neurobiological pathways have not been well understood, and there are many variants with… read more here.
Keywords: pleiotropic; depression; analysis; gene ... See more keywords
Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.140978
Abstract: ZIP8 is a metal transporter with a role in manganese (Mn) homeostasis. A common genetic variant in ZIP8 (rs13107325; A391T) ranks in the top 10 of pleiotropic SNPs identified in GWAS; A391T has associations with… read more here.
Keywords: zip8 a391t; disease; zip8; manganese homeostasis ... See more keywords
A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics
Sign Up to like & getrecommendations! Published in 2021 at "BMC Medicine"
DOI: 10.1186/s12916-021-02186-z
Abstract: Recent genome-wide association studies (GWASs) have revealed the polygenic nature of psychiatric disorders and discovered a few of single-nucleotide polymorphisms (SNPs) associated with multiple psychiatric disorders. However, the extent and pattern of pleiotropy among distinct… read more here.
Keywords: analysis; summary statistics; pleiotropic; gene ... See more keywords
Understanding the phytoestrogen genistein actions on breast cancer: Insights on estrogen receptor equivalence, pleiotropic essence and emerging paradigms in bioavailability modulation.
Sign Up to like & getrecommendations! Published in 2023 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026623666230103163023
Abstract: Prevalent as a major phenolic ingredient of soy and soy products, genistein is recognized as an eminent phytoestrogen owing to its interacting ability with estrogen receptors (ERs). The metabolic conversion of plant-derived genistin to genistein… read more here.
Keywords: phytoestrogen; pleiotropic; breast cancer; genistein actions ... See more keywords