Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2019.100203
Abstract: For several years, research from around the world has suggested that the neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (allopregnanolone) may have therapeutic potential for treatment of various stress-related diseases including post-traumatic stress disorder (PTSD), depression, alcohol use disorders… read more here.
Keywords: stress related; actions allopregnanolone; pleiotropic actions; related disease ... See more keywords
Pleiotropic Actions of PGRMC Proteins in Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac078
Abstract: Progesterone receptor membrane component (PGRMC) proteins play important roles in tumor growth, progression and chemoresistance of which PGRMC1 is the best characterized. The ancestral member predates the evolution of metazoans, so it is perhaps not… read more here.
Keywords: proteins cancer; pgrmc proteins; pleiotropic actions; actions pgrmc ... See more keywords
Editorial: Classic and Pleiotropic Actions of Vitamin D
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00341
Abstract: Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children’s Memorial Health Institute, Warsaw, Poland, 2 Sunlight, Nutrition, and Health Research Center, San Francisco, CA, United States, Department of Pediatric Rheumatology, Immunology, and Metabolic Bone Diseases,… read more here.
Keywords: classic pleiotropic; medicine; endocrinology; pleiotropic actions ... See more keywords
The PACAP Paradox: Dynamic and Surprisingly Pleiotropic Actions in the Central Regulation of Energy Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.877647
Abstract: Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), a pleiotropic neuropeptide, is widely distributed throughout the body. The abundance of PACAP expression in the central and peripheral nervous systems, and years of accompanying experimental evidence, indicates that PACAP… read more here.
Keywords: energy; pacap; pleiotropic actions; energy homeostasis ... See more keywords
Pleiotropic Actions of Aldehyde Reductase (AKR1A)
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DOI: 10.3390/metabo11060343
Abstract: We provide an overview of the physiological roles of aldehyde reductase (AKR1A) and also discuss the functions of aldose reductase (AKR1B) and other family members when necessary. Many types of aldehyde compounds are cytotoxic and… read more here.
Keywords: aldehyde reductase; reductase; actions aldehyde; akr1a ... See more keywords
COVID-19 and Other Pleiotropic Actions of Vitamin D: Proceedings from the Fifth International Conference “Vitamin D—Minimum, Maximum, Optimum” under the Auspices of the European Vitamin D Association (EVIDAS)
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DOI: 10.3390/nu15112530
Abstract: Vitamin D deficiency appeared as a worldwide pandemic markedly earlier than the COVID-19 pandemic was announced in global media [...] read more here.
Keywords: covid pleiotropic; vitamin proceedings; proceedings fifth; vitamin ... See more keywords