Identification of pleiotropic genes between risk factors of stroke by multivariate metaCCA analysis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-020-01692-8
Abstract: Genome-wide association studies (GWASs) have identified more than 20 genetic loci as risk predictors associated with stroke. However, these studies were generally performed for single-trait and failed to consider the pleiotropic effects of these risk… read more here.
Keywords: risk; analysis; risk factors; factors stroke ... See more keywords
Potential Pleiotropic Genes and Shared Biological Pathways in Epilepsy and Depression Based on GWAS Summary Statistics
Sign Up to like & getrecommendations! Published in 2022 at "Computational Intelligence and Neuroscience"
DOI: 10.1155/2022/6799285
Abstract: Current epidemiological and experimental studies have indicated the overlapping genetic foundation of epilepsy and depression. However, the detailed pleiotropic genetic etiology and neurobiological pathways have not been well understood, and there are many variants with… read more here.
Keywords: pleiotropic; depression; analysis; gene ... See more keywords
Improved Detection of Potentially Pleiotropic Genes in Coronary Artery Disease and Chronic Kidney Disease Using GWAS Summary Statistics
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.592461
Abstract: The coexistence of coronary artery disease (CAD) and chronic kidney disease (CKD) implies overlapped genetic foundation. However, the common genetic determination between the two diseases remains largely unknown. Relying on summary statistics publicly available from… read more here.
Keywords: pleiotropic genes; coronary artery; cad ckd; disease ... See more keywords