Constrained instruments and their application to Mendelian randomization with pleiotropy
Sign Up to like & getrecommendations! Published in 2019 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22184
Abstract: In Mendelian randomization (MR), inference about causal relationship between a phenotype of interest and a response or disease outcome can be obtained by constructing instrumental variables from genetic variants. However, MR inference requires three assumptions,… read more here.
Keywords: pleiotropy; mendelian randomization; genetic variants; instrumental variables ... See more keywords
The ubiquity of pleiotropy in human disease
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DOI: 10.1007/s00439-017-1854-z
Abstract: Pleiotropy has long been thought to be a common phenomenon in the human genome; however, until recently appropriate data was unavailable to test this hypothesis. Prior studies focused on assessing the prevalence of pleiotropy in… read more here.
Keywords: pleiotropy; disease; ubiquity pleiotropy; catalog ... See more keywords
Diagnostics for Pleiotropy in Mendelian Randomization Studies: Global and Individual Tests for Direct Effects
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Epidemiology"
DOI: 10.1093/aje/kwy177
Abstract: Diagnosing pleiotropy is critical for assessing the validity of Mendelian randomization (MR) analyses. The popular MR-Egger method evaluates whether there is evidence of bias-generating pleiotropy among a set of candidate genetic instrumental variables. In this… read more here.
Keywords: tests direct; pleiotropy; individual tests; mendelian randomization ... See more keywords
The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes
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DOI: 10.1093/gbe/evad044
Abstract: The pressure to survive relentless pathogen exposure explains the frequent observation that immune genes are among the fastest-evolving in the genomes of many taxa, but an intriguing proportion of immune genes also appear to be… read more here.
Keywords: immune genes; pleiotropic immune; developmental pleiotropy; pleiotropy ... See more keywords
Pleiotropy and synergistic cooperation
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DOI: 10.1371/journal.pbio.3000320
Abstract: Some forms of stable cooperation can evolve though pleiotropy with a beneficial private trait. This Formal Comment addresses a recent challenge to this idea, arguing that for synergistic, frequency-dependent cooperation, pleiotropy can raise the frequency… read more here.
Keywords: pleiotropy; synergistic cooperation; pleiotropy synergistic; biology ... See more keywords
Pleiotropy promotes the evolution of inducible immune responses in a model of host-pathogen coevolution
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1010445
Abstract: Components of immune systems face significant selective pressure to efficiently use organismal resources, mitigate infection, and resist parasitic manipulation. A theoretically optimal immune defense balances investment in constitutive and inducible immune components depending on the… read more here.
Keywords: inducible immune; pleiotropy; non pleiotropic; pleiotropic networks ... See more keywords
Elucidating the patterns of pleiotropy and its biological relevance in maize
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010664
Abstract: Pleiotropy - when a single gene controls two or more seemingly unrelated traits - has been shown to impact genes with effects on flowering time, leaf architecture, and inflorescence morphology in maize. However, the genome-wide… read more here.
Keywords: prevalence; elucidating patterns; pleiotropy; biological pleiotropy ... See more keywords
Mendelian Randomization: A Review of Methods for the Prevention, Assessment, and Discussion of Pleiotropy in Studies Using the Fat Mass and Obesity-Associated Gene as an Instrument for Adiposity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.803238
Abstract: Pleiotropy assessment is critical for the validity of Mendelian randomization (MR) analyses, and its management remains a challenging task for researchers. This review examines how the authors of MR studies address bias due to pleiotropy… read more here.
Keywords: fat mass; mendelian randomization; mass obesity; pleiotropy ... See more keywords
Cocktail-party listening and cognitive abilities show strong pleiotropy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2023.1071766
Abstract: Introduction The cocktail-party problem refers to the difficulty listeners face when trying to attend to relevant sounds that are mixed with irrelevant ones. Previous studies have shown that solving these problems relies on perceptual as… read more here.
Keywords: party; party listening; pleiotropy; cognitive abilities ... See more keywords