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   Articles with "pleomorphic xanthoastrocytoma" as a keyword



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Cytologic and histologic features of pigmented pleomorphic xanthoastrocytoma: A case report and literature review.

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recommendations! Published in 2022 at "Diagnostic cytopathology"

DOI: 10.1002/dc.24966

Abstract: In the central nervous system, the presence of pigment in astrocytic tumors is rare. Only nine cases were reported in the English literature: one ganglioglioma, one pilocytic astrocytoma, and seven cases of pleomorphic xanthoastrocytoma (PXA).… read more here.

Keywords: literature; pleomorphic xanthoastrocytoma; cytology; pigment ... See more keywords

An Infratentorial Pure Pleomorphic Xanthoastrocytoma Arising from Middle Cerebellar Peduncle: A Rare Location of an Uncommon Tumor.

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recommendations! Published in 2018 at "World neurosurgery"

DOI: 10.1016/j.wneu.2017.12.125

Abstract: BACKGROUND Pleomorphic xanthoastrocytomas are rare tumors of glial origin comprising read more here.

Keywords: cerebellar peduncle; pleomorphic xanthoastrocytoma; arising middle; middle cerebellar ... See more keywords
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Combined Diffuse Astrocytoma and Pleomorphic Xanthoastrocytoma Grade III Sharing IDH1 R132H Mutation.

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recommendations! Published in 2018 at "World neurosurgery"

DOI: 10.1016/j.wneu.2018.05.156

Abstract: BACKGROUND Collision tumors are often difficult to distinguish from intratumoral heterogeneity in diffuse gliomas. CASE DESCRIPTION We report the case of a 44-year-old woman admitted for intracranial hypertension. Magnetic resonance imaging revealed a right intra-axial… read more here.

Keywords: grade iii; idh1 r132h; pleomorphic xanthoastrocytoma; mutation ... See more keywords
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BRAF V600E, TERT, and IDH2 Mutations in Pleomorphic Xanthoastrocytoma: Observations from a Large Case-Series Study.

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recommendations! Published in 2018 at "World neurosurgery"

DOI: 10.1016/j.wneu.2018.09.050

Abstract: BACKGROUND Anaplastic pleomorphic xanthoastrocytoma (PXA) was added to grade III glial tumors as a distinct entity in the 2016 World Health Organization (WHO) classification of tumors of the central nervous system. We retrospectively reviewed and… read more here.

Keywords: braf v600e; v600e tert; pleomorphic xanthoastrocytoma; pxa ... See more keywords

Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma.

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recommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"

DOI: 10.1093/jnen/nlac044

Abstract: Composite pleomorphic xanthoastrocytoma-ganglioglioma (PXA-GG) is an extremely rare central nervous system neoplasm with 2 distinct but intermingled components. Whether this tumor represents a "collision tumor" of separate neoplasms or a monoclonal neoplasm with divergent evolution… read more here.

Keywords: pxa; xanthoastrocytoma ganglioglioma; pxa components; pleomorphic xanthoastrocytoma ... See more keywords
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Lateral ventricle pleomorphic xanthoastrocytoma concurrent with Dandy-Walker complex: A case report

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recommendations! Published in 2022 at "Medicine"

DOI: 10.1097/md.0000000000030492

Abstract: Introduction: Dandy-Walker complex and pleomorphic xanthoastrocytomas are both rare disease entities that typically manifest early in life and are associated with congenital etiological factors. Dandy-Walker complex is a cerebellar malformation associated with a series of… read more here.

Keywords: walker complex; pleomorphic xanthoastrocytoma; lateral ventricle; walker ... See more keywords
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Long-term Efficacy of Single-agent Vemurafenib for Pleomorphic Xanthoastrocytoma.

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recommendations! Published in 2018 at "Journal of Pediatric Hematology/Oncology"

DOI: 10.1097/mph.0000000000001395

Abstract: Pleomorphic xanthoastrocytoma is a malignant brain tumor that has a good prognosis with complete resection but does not respond well to chemotherapy if there is residual tumor. BRAFV600E mutations are common in pleomorphic xanthoastrocytomas and… read more here.

Keywords: term efficacy; long term; efficacy single; pleomorphic xanthoastrocytoma ... See more keywords
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A novel, potentially targetable TMEM106B-BRAF fusion in pleomorphic xanthoastrocytoma

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recommendations! Published in 2017 at "Cold Spring Harbor Molecular Case Studies"

DOI: 10.1101/mcs.a001396

Abstract: Pleomorphic xanthoastrocytoma (PXA) is a World Health Organization (WHO) Grade II glioma occurring primarily in children and young adults. Most PXAs harbor the known activating mutation BRAF V600E. We report a case of locally recurrent… read more here.

Keywords: tmem106b braf; braf; braf fusion; pleomorphic xanthoastrocytoma ... See more keywords
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pRB immunostaining in the differential diagnosis between pleomorphic xanthoastrocytoma and glioblastoma with giant cells

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recommendations! Published in 2022 at "Histopathology"

DOI: 10.1111/his.14768

Abstract: Pleomorphic xanthoastrocytoma (PXA) is a rare circumscribed glioma, characterized by frequent BRAF p. V600E mutation, and classified as grade 2 or 3. Owing to overlapping clinical–pathological features, the histological distinction from glioblastoma (GBM) with giant… read more here.

Keywords: giant cells; glioblastoma; differential diagnosis; pleomorphic xanthoastrocytoma ... See more keywords
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BRAF activating mutations involving the β3-αC loop in V600E-negative anaplastic pleomorphic xanthoastrocytoma

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recommendations! Published in 2018 at "Acta Neuropathologica Communications"

DOI: 10.1186/s40478-018-0525-1

Abstract: Anaplastic pleomorphic xanthoastrocytoma (A-PXA, WHO grade III) is a newly defined entity with highgrade histopathologic features and a propensity for recurrence [6]. While PXA with low-grade histology (WHO grade II) can harbor a recurrent valine-toglutamic… read more here.

Keywords: v600e negative; braf; kinase domain; anaplastic pleomorphic ... See more keywords
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BRAF/MEK double blockade in refractory anaplastic pleomorphic xanthoastrocytoma

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recommendations! Published in 2017 at "Neurology"

DOI: 10.1212/wnl.0000000000003767

Abstract: A 32-year-old woman was diagnosed in February 2012 with a grade II pleomorphic xanthoastrocytoma (PXA) of the right parietal lobe. A complete excision was performed, followed by tumor bed irradiation (66 Gy). A local relapse… read more here.

Keywords: xanthoastrocytoma; braf mek; mek double; blockade refractory ... See more keywords