Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2019.106580
Abstract: INTRODUCTION DSM421, a dihydroorotate dehydrogenase inhibitor, was in preclinical development as a potential treatment option for malaria. When tested in a core battery of safety pharmacology assays, DSM421 did not produce any effects at oral… read more here.
Keywords: head; head plethysmography; plethysmography testing; mortality ... See more keywords