Comparison of 3 Randomized Clinical Trials of Frontline Therapies for Malignant Pleural Mesothelioma
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.1490
Abstract: Key Points Question Are frontline therapies recommended for malignant pleural mesothelioma (MPM) associated with patient benefits? Findings In this comparative effectiveness study of 1501 participants, the statistical robustness of the Mesothelioma Cisplatin Pemetrexed Study (MPS),… read more here.
Keywords: malignant pleural; clinical trials; frontline therapies; pleural mesothelioma ... See more keywords
Disparities in Survival Due to Social Determinants of Health and Access to Treatment in US Patients With Operable Malignant Pleural Mesothelioma
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.4261
Abstract: Key Points Question What is the association of social determinants of health (SDOHs) with treatment and survival of patients with malignant pleural mesothelioma? Findings In this nationwide cohort study of 1389 adults with operable mesothelioma,… read more here.
Keywords: malignant pleural; pleural mesothelioma; mesothelioma; social determinants ... See more keywords
Prognostic risk assessment model for alternative splicing events and splicing factors in malignant pleural mesothelioma
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DOI: 10.1002/cam4.5174
Abstract: Malignant pleural mesothelioma (MPM) is a rare and highly malignant thoracic tumor. Although alternative splicing (AS) is associated with tumor prognosis, the prognostic significance of AS in MPM is unknown. read more here.
Keywords: malignant pleural; pleural mesothelioma; alternative splicing; prognostic risk ... See more keywords
Cytology of malignant pleural mesothelioma: Diagnostic criteria, WHO classification updates, and immunohistochemical staining markers diagnostic value
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25053
Abstract: Malignant pleural mesothelioma (MPM) is a rare but aggressive malignancy with a poor prognosis. Because of this tumor rarity and overlapping histologic features with other malignancy types, the histopathological findings and diagnostic immunohistochemical workup are… read more here.
Keywords: diagnostic criteria; malignant pleural; updates immunohistochemical; pleural mesothelioma ... See more keywords
Promising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK‐8628 in malignant pleural mesothelioma xenografts
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30412
Abstract: It has recently been reported that a large proportion of human malignant pleural mesothelioma (MPM) cell lines and patient tissue samples present high expression of the c‐MYC oncogene. This gene drives several tumorigenic processes and… read more here.
Keywords: mesothelioma; otx015; inhibitor otx015; bromodomain inhibitor ... See more keywords
A defect of amphiregulin release predicted longer survival independently of YAP expression in patients with pleural mesothelioma in the IFCT‐0701 MAPS phase 3 trial
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.33997
Abstract: The Hippo pathway effector YAP is dysregulated in malignant pleural mesothelioma (MPM). YAP's target genes include the secreted growth factor amphiregulin (AREG), which is overexpressed in a wide range of epithelial cancers and plays an… read more here.
Keywords: cell; expression; ifct 0701; pleural mesothelioma ... See more keywords
Contemporary issues in the surgical management of pleural mesothelioma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.27152
Abstract: The surgical management of pleural mesothelioma (PM) can be divided into diagnostic, staging, palliation, and cytoreductive surgery. In the cytoreductive surgical setting, the combination of different treatment modalities has led to better outcomes than surgery… read more here.
Keywords: pleural mesothelioma; management; mesothelioma; contemporary issues ... See more keywords
Malignant pleural mesothelioma characteristics and outcomes: A SEER-Medicare analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of surgical oncology"
DOI: 10.1002/jso.27243
Abstract: BACKGROUND Pleural mesothelioma is rare cancer linked to asbestos exposure. Previous research has indicated that female individuals have better survival than male individuals, but this has never been examined in the Surveillance, Epidemiology, and End… read more here.
Keywords: malignant pleural; seer medicare; pleural mesothelioma; analysis ... See more keywords
Multi-institutional survey of malignant pleural mesothelioma patients in the Hokushin region
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03699-z
Abstract: Malignant pleural mesothelioma (MPM) is a major occupational and environmental neoplasm. The purpose of this study was to validate the clinical and epidemiological factors, diagnosis, and initial treatment among MPM patients in the Hokushin region.… read more here.
Keywords: mpm; patients hokushin; pleural mesothelioma; malignant pleural ... See more keywords
Surgical strategy for malignant pleural mesothelioma: the superiority of pleurectomy/decortication
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DOI: 10.1007/s00595-021-02437-9
Abstract: Both extrapleural pneumonectomy (EPP) and pleurectomy/decortication (P/D) are used for the surgical treatment of malignant pleural mesothelioma (MPM). This study aimed to compare the operative and clinical outcomes and survival between EPP and P/D. We… read more here.
Keywords: pleural mesothelioma; malignant pleural; pleurectomy decortication;
4EGI-1 represses cap-dependent translation and regulates genome-wide translation in malignant pleural mesothelioma
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0535-z
Abstract: SummaryDeregulation of cap-dependent translation has been implicated in the malignant transformation of numerous human tissues. 4EGI-1, a novel small-molecule inhibitor of cap-dependent translation, disrupts formation of the eukaryotic initiation factor 4F (eIF4F) complex. The effects… read more here.
Keywords: genome wide; dependent translation; pleural mesothelioma; malignant pleural ... See more keywords