Semi‐synthesis, antibacterial activity, and molecular docking study of novel pleuromutilin derivatives bearing cinnamic acids moieties
Sign Up to like & getrecommendations! Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800266
Abstract: To develop new antibiotics owning a special mechanism, we used the molecular assembly method to synthesize a series of novel pleuromutilin derivatives containing a cinnamic acid scaffold at the C‐14 side chain. We evaluated their… read more here.
Keywords: study; antibacterial activity; pleuromutilin derivatives; activity ... See more keywords
Design, synthesis, and biological evaluation of pleuromutilin derivatives containing 1,2,4-triazole linker.
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DOI: 10.1002/ddr.22050
Abstract: A series of thioether pleuromutilin derivatives containing 1,2,4‐triazole on the side chain of C14 were designed and synthesized. The in vitro antibacterial activities experiments of the synthesized derivatives showed that compounds 72 and 73 displayed… read more here.
Keywords: design synthesis; synthesis biological; containing triazole; pleuromutilin derivatives ... See more keywords
Synthesis and antibacterial activities of novel pleuromutilin derivatives with a substituted pyrimidine moiety.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.054
Abstract: The alarming growth of multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) has become a major global health hazard. Therefore, urgent demand for new antibiotics with a unique mechanism of action… read more here.
Keywords: derivatives substituted; synthesis antibacterial; pleuromutilin derivatives; antibacterial activities ... See more keywords
Discovery of Novel Pleuromutilin Derivatives as Potent Antibacterial Agents for the Treatment of MRSA Infection
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030931
Abstract: A series of novel pleuromutilin derivatives containing nitrogen groups on the side chain of C14 were synthesized under mild conditions. Most of the synthesized derivatives displayed potent antibacterial activities. Compound 9 was found to be… read more here.
Keywords: compound; potent antibacterial; novel pleuromutilin; pleuromutilin derivatives ... See more keywords