The pineapple technique for excision of large plexiform neurofibromas
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Plastic Surgery"
DOI: 10.1007/s00238-017-1292-0
Abstract: Plexiform neurofibromas (PNF) occur in up to 30% of patients with neurofibromatosis type 1 (NF1). To date, management of this tumors remains medically challenging. Surgical approach represents the only viable treatment option of progressive growing… read more here.
Keywords: technique; plexiform neurofibromas; plexiform; excision ... See more keywords
Fluorescein-guided resection of plexiform neurofibromas: how I do it
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-019-04038-5
Abstract: Plexiform neurofibromas (PN) can determine pain, nerve function impairment, and, when extremely large, also deformity. Surgical is often partial, with possible recurrence, and the risk of malignant transformation. We describe the surgical strategy in a… read more here.
Keywords: plexiform; fluorescein guided; plexiform neurofibromas; resection ... See more keywords
Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110385
Abstract: Plexiform neurofibromas (pNFs) are developmental tumors that appear in neurofibromatosis type 1 individuals, constituting a major source of morbidity and potentially transforming into a highly metastatic sarcoma (MPNST). pNFs arise after NF1 inactivation in a… read more here.
Keywords: like tumors; ipsc derived; ipsc; modeling ipsc ... See more keywords
Trametinib Induces Neurofibroma Shrinkage and Enables Surgery.
Sign Up to like & getrecommendations! Published in 2019 at "Neuropediatrics"
DOI: 10.1055/s-0039-1691830
Abstract: Plexiform neurofibromas are congenital peripheral nerve sheath tumors characteristic of neurofibromatosis type 1 (NF1)-a frequent neurocutaneous disorder caused by mutations of the NF1 tumor suppressor gene. Since plexiform neurofibromas are a major cause of the… read more here.
Keywords: surgery; plexiform neurofibromas; induces neurofibroma; plexiform ... See more keywords
Management of Neurofibromatosis Type 1-Associated Plexiform Neurofibromas.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac146
Abstract: Plexiform Neurofibromas (PN) are a common manifestation of the genetic disorder neurofibromatosis type 1 (NF1). These benign nerve sheath tumors often cause significant morbidity, with treatment options limited historically to surgery. There have been tremendous… read more here.
Keywords: management; plexiform neurofibromas; neurofibromatosis type;
Abstract PR07: Phase II Trial of the MEK 1/2 inhibitor selumetinib (AZD6344, ARRY-142886 hydrogen sulphate) in adults with neurofibromatosis type 1 (NF1) and inoperable plexiform neurofibromas (PN)
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-pr07
Abstract: Background: Neurofibromatosis type 1 (NF1)-related plexiform neurofibromas (PN) are locally invasive tumors that can cause debilitating complications including pain, disfigurement, and functional limitations. The primary treatment option is surgical debulking, which is often challenging and… read more here.
Keywords: neurofibromatosis type; mek; plexiform neurofibromas; nf1 inoperable ... See more keywords
Nerve ultrasound
Sign Up to like & getrecommendations! Published in 2017 at "Neurology"
DOI: 10.1212/wnl.0000000000003870
Abstract: Objective: To determine ultrasonographic peripheral nerve involvement in patients with asymptomatic neurofibromatosis type 1 (NF1). Methods: Thirteen asymptomatic and 4 minimally symptomatic patients with NF1 were included in this cross-sectional pilot study to detect asymptomatic… read more here.
Keywords: nerve ultrasound; plexiform neurofibromas; hrus; nerve ... See more keywords
Integrated Drug Mining Reveals Actionable Strategies Inhibiting Plexiform Neurofibromas
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12060720
Abstract: Neurofibromatosis Type 1 (NF1) is one of the most common genetic tumor predisposition syndromes, affecting up to 1 in 2500 individuals. Up to half of patients with NF1 develop benign nerve sheath tumors called plexiform… read more here.
Keywords: drug mining; integrated drug; plexiform neurofibromas; mining reveals ... See more keywords