Semaphorin 3E–Plexin D1 Axis Drives Lung Fibrosis through ErbB2‐Mediated Fibroblast Activation
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DOI: 10.1002/advs.202415007
Abstract: Idiopathic pulmonary fibrosis (IPF) is characterized by excessive fibroblast recruitment and persistent extracellular matrix deposition at sites of tissue injury, leading to severe morbidity and mortality. However, the precise mechanisms by which fibroblasts contribute to… read more here.
Keywords: plexin; fibroblast activation; p61 sema3e; fibrosis ... See more keywords
Hybrid in vitro/in silico analysis of low‐affinity protein–protein interactions that regulate signal transduction by Sema6D
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4452
Abstract: Semaphorins constitute a large family of secreted and membrane‐bound proteins that signal through cell‐surface receptors, plexins. Semaphorins generally use low‐affinity protein–protein interactions to bind with their specific plexin(s) and regulate distinct cellular processes such as… read more here.
Keywords: sema6d; affinity; class; analysis ... See more keywords
Sema6A‐plexin‐A2 axis stimulates RANKL‐induced osteoclastogenesis through PLC&ggr;‐mediated NFATc1 activation
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.01.060
Abstract: &NA; Recently, several plexins and semaphorins have been associated with osteoclastogenesis, a vital process for bone remodeling. Plexin‐A2 is implicated in bone homeostasis, however, whether it plays a role in osteoclastogenesis and the underlying mechanism… read more here.
Keywords: induced osteoclastogenesis; plexin; rankl induced; sema6a plexin ... See more keywords
Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-47424-z
Abstract: Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton. The exact extent of these effects on tumour-specific T cells are not completely understood.… read more here.
Keywords: cd8 cells; cd8; tumour; cell ... See more keywords
ANGI-17. REGULATION OF PLASMA MEMBRANE TENSION BY PLEXIN RECEPTORS FACILITATES INVASION OF GBM THROUGH CONFINED SPACE
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0083
Abstract: Invading Glioblastoma (GBM) cells experience strong physical constraints and face severe mechanical challenges when they squeeze through tight, confined interstitial space. How GBM cells adapt to confined space to achieve the typical diffuse, invasive migration… read more here.
Keywords: space; gbm cells; gbm; membrane tension ... See more keywords
Identification of Plexin D1 on circulating extracellular vesicles as a potential biomarker of polymyositis and dermatomyositis.
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab588
Abstract: OBJECTIVES We aimed to identify disease-specific surface proteins on extracellular vesicles (EVs) as novel serum biomarkers of polymyositis and dermatomyositis (PM/DM). METHODS We performed liquid chromatography-tandem mass spectrometry (LC/MS) on purified EVs from sera of… read more here.
Keywords: extracellular vesicles; polymyositis dermatomyositis; plexin; plexin evs ... See more keywords
Immune-Mediated Small Fiber Neuropathy With Trisulfated Heparin Disaccharide, Fibroblast Growth Factor Receptor 3, or Plexin D1 Antibodies: Presentation and Treatment With Intravenous Immunoglobulin
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Neuromuscular Disease"
DOI: 10.1097/cnd.0000000000000423
Abstract: Abstract Objectives: Up to 50% of small fiber neuropathy (SFN) cases are idiopathic, but novel antibodies to Trisulfated Heparin Disaccharide (TS-HDS) and fibroblast growth factor receptor 3 (FGFR-3) have been implicated in half of these… read more here.
Keywords: fiber neuropathy; fiber; plexin; small fiber ... See more keywords
Effectiveness of IVIG on Non–Length-Dependent Skin Biopsies in Small Fiber Neuropathy With Plexin D1, Trisulfated Heparin Disaccharide, and Fibroblast Growth Factor Receptor 3 Autoantibodies
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Neuromuscular Disease"
DOI: 10.1097/cnd.0000000000000485
Abstract: Objectives: To demonstrate treatment efficacy on composite and non–length-dependent (NLD) punch biopsy specimens from intravenous immunoglobulin (IVIG) in pure small-fiber neuropathy (SFN) with trisulfated heparin disaccharide (TS-HDS), fibroblast growth factor-3 (FGFR-3), or Plexin D1 antibodies.… read more here.
Keywords: length dependent; treatment; ivig; sfn ... See more keywords
A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abf1922
Abstract: Peptic ulcer disease is a frequent clinical problem with potentially serious complications such as bleeding or perforation. A decisive factor in the pathogenesis of peptic ulcers is gastric acid, the secretion of which is controlled… read more here.
Keywords: signaling pathway; peptic ulcers; gastric acid; semaphorin plexin ... See more keywords
Abstract B48: Targeting the semaphorin 4D-plexin B axis to augment FOLFIRINOX in a murine model of pancreatic adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.panca19-b48
Abstract: Background: Pancreatic adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality, with dismal 5-year prognosis of 8%, in part due to poor response to available therapies. Thus, new systemic cancer control therapies are in… read more here.
Keywords: sema4d; murine; murine model; plexin ... See more keywords
MiR-362-5p inhibits cartilage repair in osteoarthritis via targeting plexin B1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Surgery"
DOI: 10.1177/10225536221139887
Abstract: Background and objectives Chondrogenesis of bone marrow mesenchymal stem cells (BMSCs) exerts great function during the pathogenesis of osteoarthritis (OA). Studies have reported the association of plexin B1 (PLXNB1) with OA pathogenesis. In this study,… read more here.
Keywords: chondrogenic differentiation; plxnb1; osteoarthritis; plexin ... See more keywords