Hybrid in vitro/in silico analysis of low‐affinity protein–protein interactions that regulate signal transduction by Sema6D
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4452
Abstract: Semaphorins constitute a large family of secreted and membrane‐bound proteins that signal through cell‐surface receptors, plexins. Semaphorins generally use low‐affinity protein–protein interactions to bind with their specific plexin(s) and regulate distinct cellular processes such as… read more here.
Keywords: sema6d; affinity; class; analysis ... See more keywords
Sema6A‐plexin‐A2 axis stimulates RANKL‐induced osteoclastogenesis through PLC&ggr;‐mediated NFATc1 activation
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.01.060
Abstract: &NA; Recently, several plexins and semaphorins have been associated with osteoclastogenesis, a vital process for bone remodeling. Plexin‐A2 is implicated in bone homeostasis, however, whether it plays a role in osteoclastogenesis and the underlying mechanism… read more here.
Keywords: induced osteoclastogenesis; plexin; rankl induced; sema6a plexin ... See more keywords
Identification of Plexin D1 on circulating extracellular vesicles as a potential biomarker of polymyositis and dermatomyositis.
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab588
Abstract: OBJECTIVES We aimed to identify disease-specific surface proteins on extracellular vesicles (EVs) as novel serum biomarkers of polymyositis and dermatomyositis (PM/DM). METHODS We performed liquid chromatography-tandem mass spectrometry (LC/MS) on purified EVs from sera of… read more here.
Keywords: extracellular vesicles; polymyositis dermatomyositis; plexin; plexin evs ... See more keywords
Immune-Mediated Small Fiber Neuropathy With Trisulfated Heparin Disaccharide, Fibroblast Growth Factor Receptor 3, or Plexin D1 Antibodies: Presentation and Treatment With Intravenous Immunoglobulin
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Neuromuscular Disease"
DOI: 10.1097/cnd.0000000000000423
Abstract: Abstract Objectives: Up to 50% of small fiber neuropathy (SFN) cases are idiopathic, but novel antibodies to Trisulfated Heparin Disaccharide (TS-HDS) and fibroblast growth factor receptor 3 (FGFR-3) have been implicated in half of these… read more here.
Keywords: fiber neuropathy; fiber; plexin; small fiber ... See more keywords
A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abf1922
Abstract: Peptic ulcer disease is a frequent clinical problem with potentially serious complications such as bleeding or perforation. A decisive factor in the pathogenesis of peptic ulcers is gastric acid, the secretion of which is controlled… read more here.
Keywords: signaling pathway; peptic ulcers; gastric acid; semaphorin plexin ... See more keywords
Abstract B48: Targeting the semaphorin 4D-plexin B axis to augment FOLFIRINOX in a murine model of pancreatic adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.panca19-b48
Abstract: Background: Pancreatic adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality, with dismal 5-year prognosis of 8%, in part due to poor response to available therapies. Thus, new systemic cancer control therapies are in… read more here.
Keywords: sema4d; murine; murine model; plexin ... See more keywords
MiR-362-5p inhibits cartilage repair in osteoarthritis via targeting plexin B1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Surgery"
DOI: 10.1177/10225536221139887
Abstract: Background and objectives Chondrogenesis of bone marrow mesenchymal stem cells (BMSCs) exerts great function during the pathogenesis of osteoarthritis (OA). Studies have reported the association of plexin B1 (PLXNB1) with OA pathogenesis. In this study,… read more here.
Keywords: chondrogenic differentiation; plxnb1; osteoarthritis; plexin ... See more keywords
Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins
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DOI: 10.1371/journal.pone.0185899
Abstract: The Rnd family of proteins, Rnd1, Rnd2 and Rnd3, are atypical Rho family GTPases, which bind to but do not hydrolyse GTP. They interact with plexins, which are receptors for semaphorins, and are hypothesised to… read more here.
Keywords: plexin rbd; plexin; plexin plexin; family ... See more keywords
Plexin-B3 Regulates Cellular Motility, Invasiveness, and Metastasis in Pancreatic Cancer
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DOI: 10.3390/cancers13040818
Abstract: Simple Summary Plexins and their ligands Semaphorins are considered versatile regulators of cancer cell migration, angiogenesis, invasion, and metastasis. Previously our group identified Semaphorin-5A (SEMA5A), the ligand of Plexin-B3, involved in organ-specific homing of pancreatic… read more here.
Keywords: plexin; pancreatic cancer; metastasis; expression ... See more keywords
Endothelial semaphorin 7A promotes seawater aspiration-induced acute lung injury through plexin C1 and β1 integrin.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7097
Abstract: Inflammation and edema are two main characteristics in seawater aspiration‑induced acute lung injury (ALI). In a previous study of the authors, it was demonstrated that endothelial semaphorin 7A (SEMA7A) serves an important role in the… read more here.
Keywords: sema7a; plexin; seawater aspiration; aspiration induced ... See more keywords