Dual-Modality Poly-l-histidine Nanoparticles to Deliver Peptide Nucleic Acids and Paclitaxel for In Vivo Cancer Therapy.
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DOI: 10.1021/acsami.1c11981
Abstract: Cationic polymeric nanoformulations have been explored to increase the transfection efficiency of small molecules and nucleic acid-based drugs. However, an excessive positive charge density often leads to severe cell and tissue-based toxicity that restricts the… read more here.
Keywords: histidine; peptide nucleic; histidine nanoparticles; poly histidine ... See more keywords