Clinical Evidence of Granulocyte-Monocyte Progenitor (GMP) Stem Cell Involvement in Plinabulin's Mechanism of Action (MoA) for the Prevention of Docetaxel (Doc) Chemotherapy (Chemo)-Induced Neutropenia (CIN)
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DOI: 10.1182/blood-2019-127227
Abstract: Introduction: Plinabulin (Plin) is being developed as a novel non-Granulocyte colony stimulating factor (G-CSF) for CIN prevention. Previously we reported that Plin was equally effective as Pegfilgrastim for the prevention of grade 4 CIN in… read more here.
Keywords: cin; doc; chemo induced; prevention ... See more keywords
Plinabulin (Plin) combined with half-dose pegfilgrastim (Peg) compared with full-dose peg alone for chemotherapy- induced-neutropenia (CIN): Neutrophil, bone pain, and immunosuppressive effects.
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DOI: 10.1200/jco.2019.37.15_suppl.e12017
Abstract: e12017 Background: Peg is used for CIN prevention. Plin, a novel, non-G-CSF agent is in Phase (Ph) 3 trials for CIN prevention and as an anticancer (NSCLC) agent. In contrast to Peg, Plin does not… read more here.
Keywords: bone pain; plin; peg; dose peg ... See more keywords
A phase II trial with the combination of plinabulin (plin) pegfilgrastim (peg): Evaluation of the reversal of peg’s immune-suppressive potential by the addition of plin to peg.
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DOI: 10.1200/jco.2019.37.8_suppl.4
Abstract: 4 Background: Peg is a long-acting G-CSF used for prevention of Chemotherapy Induced Neutropenia (CIN). Peg stimulates granulopoiesis in bone marrow and causes a temporary overshoot in absolute neutrophil count (ANC). High NLR is a… read more here.
Keywords: immune suppressive; plin peg; nlr lmr; plin ... See more keywords