Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108718
Abstract: BACKGROUND Perilipin 5 (Plin5) acts as a pivotal mediator of oxidative stress and inflammation and is associated with the progression of relevant diseases. Cerebral ischemic stroke is a severe pathological condition that involves excess oxidative… read more here.
Keywords: ischemic stroke; oxidative stress; plin5; cerebral ischemic ... See more keywords
Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.12.003
Abstract: Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and oxidative metabolism via a SIRT1/PGC-1α/PPARα-dependent pathway through an… read more here.
Keywords: allosterically activate; activate sirt1; fatty acids; derived monounsaturated ... See more keywords
Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular research"
DOI: 10.1093/cvr/cvz119
Abstract: Aims Lipotoxic cardiomyopathy in diabetic and obese patients typically encompasses increased cardiac fatty acid (FA) uptake eventually surpassing the mitochondrial oxidative capacity. Lowering FA utilization via inhibition of lipolysis represents a strategy to counteract the… read more here.
Keywords: heart; heart dysfunction; lipolysis; mice ... See more keywords
Plin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/8690746
Abstract: Background Hyper-free fatty acidemia (HFFA) impairs cardiac capillaries, as well as type 2 diabetes mellitus (T2DM). Perilipin 5 (Plin5) maintains metabolic balance of free fatty acids (FFAs) in high oxidative tissues via the states of… read more here.
Keywords: cmecs regulating; regulating ffas; diabetic cmecs; ffas metabolism ... See more keywords
Plin5 Bidirectionally Regulates Lipid Metabolism in Oxidative Tissues
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4594956
Abstract: Cytoplasmic lipid droplets (LDs) can store neutral lipids as an energy source when needed and also regulate the key metabolic processes of intracellular lipid accumulation, which is associated with several metabolic diseases. The perilipins (Plins)… read more here.
Keywords: oxidative tissues; plin5; plin5 bidirectionally; lipid metabolism ... See more keywords
Perilipin 5 alleviates HCV NS5A-induced lipotoxic injuries in liver
Sign Up to like & getrecommendations! Published in 2019 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-019-1022-7
Abstract: BackgroundThe homeostasis of lipid droplets (LDs) plays a crucial role in maintaining the physical metabolic processes in cells, and is regulated by many LD-associated proteins, including perilipin 5 (Plin5) in liver. As the putative sites… read more here.
Keywords: ns5a induced; ns5a expression; liver hepatocytes; lipotoxic injuries ... See more keywords
Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting[S]
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Lipid Research"
DOI: 10.1194/jlr.ra119000336
Abstract: Lipid droplets (LDs) are energy-storage organelles that are coated with hundreds of proteins, including members of the perilipin (PLIN) family. PLIN5 is highly expressed in oxidative tissues, including the liver, and is thought to play… read more here.
Keywords: autophagy; plin5; promote autophagy; autophagy prevent ... See more keywords
Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility
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DOI: 10.26508/lsa.202201690
Abstract: We show that elevated cardiac Plin5 correlates with up-regulation of cardiac contraction–related processes, unraveling a novel Plin5 interaction with SERCA2 associated with improved calcium handling. The adult heart develops hypertrophy to reduce ventricular wall stress… read more here.
Keywords: calcium handling; hypertrophy; plin5; cardiomyocyte ... See more keywords
Lipid-Independent Regulation of PLIN5 via IL-6 through the JAK/STAT3 Axis in Hep3B Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087219
Abstract: Perilipin 5 (PLIN5) is a lipid droplet coat protein that is highly expressed in oxidative tissues such as those of muscles, the heart and the liver. PLIN5 expression is regulated by a family of peroxisome… read more here.
Keywords: plin5 expression; plin5; regulation plin5; jak stat3 ... See more keywords