Articles with "plk" as a keyword



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Pharmacoinformatics approach for the identification of Polo-like kinase-1 inhibitors from natural sources as anti-cancer agents.

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Published in 2018 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2018.05.023

Abstract: Polo-like kinase-1 (PLK-1) plays a key role in cell cycle progression during mitosis. Overexpression/dysfunction of PLK-1 is directly associated with cancerous transformation and has been reported in different cancer types. Here, we employed high throughput… read more here.

Keywords: like kinase; kinase; polo like; hesperidin ... See more keywords
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Study on Pharmacokinetics and Metabolic Profiles of Novel Potential PLK-1 Inhibitors by UHPLC-MS/MS Combined with UHPLC-Q-Orbitrap/HRMS

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Published in 2023 at "Molecules"

DOI: 10.3390/molecules28062550

Abstract: PLK-1 (Polo-like kinase-1) plays an essential role in cytokinesis, and its aberrant expression is considered to be keenly associated with a wide range of cancers. It has been selected as an appealing target and small-molecule… read more here.

Keywords: orbitrap hrms; compound; plk inhibitors; uhplc orbitrap ... See more keywords