Exploration of the Combination of PLK1 Inhibition with Immunotherapy in Cancer Treatment
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Oncology"
DOI: 10.1155/2018/3979527
Abstract: Background PLK1 overexpression is oncogenic and is associated with poor prognosis in various cancers. However, the current PLK1 inhibitors have achieved limited clinical successes. On the other hand, although immunotherapies are demonstrating efficacy in treating… read more here.
Keywords: cancer; tumor immunity; plk1 inhibition; inhibition immunotherapy ... See more keywords
Non‐canonical cMet regulation by vimentin mediates Plk1 inhibitor–induced apoptosis
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DOI: 10.15252/emmm.201809960
Abstract: To address the need for improved systemic therapy for non–small‐cell lung cancer (NSCLC), we previously demonstrated that mesenchymal NSCLC was sensitive to polo‐like kinase (Plk1) inhibitors, but the mechanisms of resistance in epithelial NSCLC remain… read more here.
Keywords: inhibitor induced; induced apoptosis; inhibition; plk1 inhibition ... See more keywords
Present and Future Perspective on PLK1 Inhibition in Cancer Treatment
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DOI: 10.3389/fonc.2022.903016
Abstract: Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine kinase family. PLK1 has a key role in the progression of mitosis and recent evidence suggest its important involvement in regulating the… read more here.
Keywords: plk1; present future; plk1 inhibition; future perspective ... See more keywords
PLK1 Inhibition Induces Immunogenic Cell Death and Enhances Immunity against NSCLC
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DOI: 10.7150/ijms.60135
Abstract: PLK1 inhibitors were shown, in vitro and in vivo, to possess inhibitory activities against non-small cell lung cancer (NSCLC), and such inhibition has been proven by clinical trials. However, it remains unclear whether and how… read more here.
Keywords: immunogenic cell; cell; plk1 inhibition; cell death ... See more keywords