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   Articles with "plk2" as a keyword



Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.11.025

Abstract: The protein deacetylase SIRT1 (Sirtuin 1) regulates many cellular processes, including cell-cycle progression, DNA damage response, and metabolism. Although the centrosome is a key regulator of cell-cycle progression and genome stability, little is known concerning… read more here.

Keywords: sirt1; deacetylase sirt1; centriole duplication; plk2 ... See more keywords

PLK2 disrupts autophagic flux to promote SNCA/α-synuclein pathology

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recommendations! Published in 2025 at "Autophagy"

DOI: 10.1080/15548627.2024.2448914

Abstract: ABSTRACT The aggregation and transmission of SNCA/α-synuclein (synuclein, alpha) is a hallmark pathology of Parkinson disease (PD). PLK2 (polo like kinase 2) is an evolutionarily conserved serine/threonine kinase that is more abundant in the brains… read more here.

Keywords: snca synuclein; pathology; plk2; kinase ... See more keywords

Polo-like kinase 2 ameliorates lipopolysaccharide-induced cardiac injury by blocking cardiomyocyte ferroptosis.

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recommendations! Published in 2025 at "American journal of hypertension"

DOI: 10.1093/ajh/hpaf001

Abstract: BACKGROUND Polo-like kinase 2 (PLK2) is associated with cardiac fibrosis in patients with atrial fibrillation. However, the role of PLK2 in sepsis-induced cardiac injury has not been fully elucidated. We hypothesize that PLK2 may participate… read more here.

Keywords: cardiac injury; plk2; ferroptosis; injury ... See more keywords

Polo-Like Kinase 2: From Principle to Practice

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recommendations! Published in 2022 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2022.956225

Abstract: Polo-like kinase (PLK) 2 is an evolutionarily conserved serine/threonine kinase that shares the n-terminal kinase catalytic domain and the C-terminal Polo Box Domain (PBD) with other members of the PLKs family. In the last two… read more here.

Keywords: polo like; like kinase; kinase; principle practice ... See more keywords