FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity
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DOI: 10.1038/s42003-020-01161-3
Abstract: Polo like kinase 4 (Plk4) is a tightly regulated serine threonine kinase that governs centriole duplication. Increased Plk4 expression, which is a feature of many common human cancers, causes centriole overduplication, mitotic irregularities, and chromosomal instability.… read more here.
Keywords: plk4; tumor suppressor; fam46c tent5c; activity ... See more keywords