Intracellular Delivery of Glucose Oxidase for Enhanced Cytotoxicity toward PSMA-Expressing Prostate Cancer Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201900183
Abstract: Reactive oxygen species (ROS) forming enzymes are of significant interest as anticancer agents due to their potent cytotoxicity. A key challenge in their clinical translation is attaining site-specific delivery and minimizing biodistribution to healthy tissues.… read more here.
Keywords: delivery; glucose oxidase; pll peg; cancer ... See more keywords
Complexation of Chol‐DsiRNA in place of Chol‐siRNA greatly increases the duration of mRNA suppression by polyplexes of PLL(30)‐PEG(5K) in primary murine syngeneic breast tumors after i.v. administration
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.03.045
Abstract: &NA; RNA interference has tremendous potential for cancer therapy but is limited by the insufficient potency of RNAi molecules after i.v. administration. We previously found that complexation with PLL(30)‐PEG(5K) greatly increases the potency of 3′‐cholesterol‐modified… read more here.
Keywords: suppression; chol dsirna; chol sirna; pll peg ... See more keywords