Unveiling the phantom: What neuroimaging has taught us about phantom limb pain
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2509
Abstract: Phantom limb pain (PLP) is a complicated condition with diverse clinical challenges. It consists of pain perception of a previously amputated limb. The exact pain mechanism is disputed and includes mechanisms involving cerebral, peripheral, and… read more here.
Keywords: plp; phantom; phantom limb; limb pain ... See more keywords
Free energy landscapes of prototropic tautomerism in pyridoxal 5′‐phosphate schiff bases at the active site of an enzyme in aqueous medium
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.25338
Abstract: We have performed hybrid quantum‐classical metadynamics simulations and quantum chemical calculations to investigate the free energy landscapes of intramolecular proton transfer and associated tautomeric equilibrium in pyridoxal 5 ′ ‐phosphate (PLP) Schiff Bases, namely the… read more here.
Keywords: energy landscapes; plp; active site; free energy ... See more keywords
Disorders affecting vitamin B6 metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12060
Abstract: Vitamin B6 is present in our diet in many forms, however, only pyridoxal 5′‐phosphate (PLP) can function as a cofactor for enzymes. The intestine absorbs nonphosphorylated B6 vitamers, which are converted by specific enzymes to… read more here.
Keywords: plp; vitamin metabolism; metabolism; role plp ... See more keywords
Crystal structures clarify cofactor binding of plant tyrosine decarboxylase.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.12.077
Abstract: Plant tyrosine decarboxylase (TyrDC) is a group II pyridoxal 5'-phosphate (PLP)-dependent decarboxylase that mainly catalyzes the decarboxylation of tyrosine to tyramine. This is biologically important for diverting essential primary metabolites into secondary metabolic pathways. Intensive… read more here.
Keywords: plp; plp binding; decarboxylase; plant tyrosine ... See more keywords
Vitamin B6 deficiency with normal plasma levels of pyridoxal 5'-phosphate in perinatal hypophosphatasia.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116007
Abstract: Pyridoxal 5'-phosphate (PLP), the principal circulating form of vitamin B6 (B6), is elevated in the plasma of individuals with hypophosphatasia (HPP). HPP is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of ALPL, the gene that encodes… read more here.
Keywords: plp; plasma; level; pyridoxal phosphate ... See more keywords
Hypophosphatasia: Vitamin B6 status of affected children and adults.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116204
Abstract: Hypophosphatasia (HPP) is the heritable dento-osseous disease caused by loss-of-function mutation(s) of the gene ALPL that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP is a cell-surface homodimeric phosphomonoester phosphohydrolase expressed in healthy people… read more here.
Keywords: affected children; plp; children adults; hpp ... See more keywords
Vitamin B6 in acute encephalopathy with biphasic seizures and late reduced diffusion
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Development"
DOI: 10.1016/j.braindev.2020.02.002
Abstract: BACKGROUND The initial presentation of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is indistinguishable from that of complex febrile seizures (FS), which poses a great diagnostic challenge for clinicians. Excitotoxicity is speculated… read more here.
Keywords: plp; seizures late; encephalopathy biphasic; acute encephalopathy ... See more keywords
Construction and Application of PLP Self-sufficient Biocatalysis System for Threonine Aldolase.
Sign Up to like & getrecommendations! Published in 2020 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2020.109667
Abstract: A number of organic synthesis involve threonine aldolase (TA), a pyridoxal phosphate (PLP)-dependent enzyme. Although the addition of exogenous PLP is necessary for the reactions, it increases the cost and complicates the purification of the… read more here.
Keywords: bnlta; plp; system; plp self ... See more keywords
Crystal structure of a novel type of ornithine δ-aminotransferase from the hyperthermophilic archaeon Pyrococcus horikoshii.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.03.114
Abstract: Ornithine δ-aminotransferase (Orn-AT) activity was detected for the enzyme annotated as a γ-aminobutyrate aminotransferase encoded by PH1423 gene from Pyrococcus horikoshii OT-3. Crystal structures of this novel archaeal ω-aminotransferase were determined for the enzyme in… read more here.
Keywords: plp; aminotransferase; pyrococcus horikoshii; ornithine aminotransferase ... See more keywords
Understanding intracortical excitability in phantom limb pain: A multivariate analysis from a multicenter randomized clinical trial
Sign Up to like & getrecommendations! Published in 2021 at "Neurophysiologie Clinique"
DOI: 10.1016/j.neucli.2020.12.006
Abstract: OBJECTIVES To explore associations of intracortical excitability with clinical characteristics in a large sample of subjects with phantom limb pain (PLP). METHODS Ancillary study using baseline and longitudinal data from a large multicenter randomized trial… read more here.
Keywords: plp; intracortical excitability; excitability; phantom limb ... See more keywords
Effectiveness of mirror therapy in phantom limb pain: a literature review
Sign Up to like & getrecommendations! Published in 2018 at "Neurologia"
DOI: 10.1016/j.nrleng.2018.08.005
Abstract: Abstract Introduction Phantom limb pain (PLP) is a type of neuropathic pain that affects the territory of an amputated limb or other surgically removed body parts. Between 60% and 90% of amputees suffer from PLP… read more here.
Keywords: plp; mirror therapy; review; phantom limb ... See more keywords