Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2
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DOI: 10.3390/cancers13164009
Abstract: Simple Summary The mitochondrial enzyme serine hydroxymethyltransferase (SHMT2), which converts serine into glycine and generates 1C units for cell growth, is one of the most consistently overexpressed metabolic enzymes in cancer. Here, we reveal that… read more here.
Keywords: inhibitor; plp competitive; metformin; shmt2 ... See more keywords