Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT
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DOI: 10.1101/2022.07.25.501395
Abstract: The eukaryotic chaperonin TRiC/CCT assists the folding of ~10% cytosolic proteins. The essential cytoskeletal proteins tubulin and actin are the obligate substrates of TRiC and their folding involves cochaperone and co-factors. Here, through cryo-EM analysis,… read more here.
Keywords: state; structural basis; plp2; tric cct ... See more keywords
Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction
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DOI: 10.3390/v11100896
Abstract: The papain-like cysteine protease 2 (PLP2) within the N-terminus of the porcine reproductive and respiratory syndrome virus (PRRSV) nsp2 replicase protein specifies a deubiquitinating enzyme (DUB), but its biochemical properties and the role in infection… read more here.
Keywords: dub activity; cleavage; plp2; prrsv nsp2 ... See more keywords