Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease
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DOI: 10.1021/acs.jmedchem.2c00303
Abstract: SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The approval of vaccines and small-molecule antivirals is vital in combating the pandemic. The viral polymerase inhibitors remdesivir and molnupiravir and the viral main protease inhibitor… read more here.
Keywords: protease; like protease; plpro inhibitors; cov papain ... See more keywords
SARS-CoV-2 Papain-Like Protease Potential Inhibitors—In Silico Quantitative Assessment
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DOI: 10.3390/ijms22083957
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes the papain-like protease (PLpro). The protein not only plays an essential role in viral replication but also cleaves ubiquitin and ubiquitin-like interferon-stimulated gene 15 protein (ISG15) from… read more here.
Keywords: like protease; sars cov; papain like; plpro inhibitors ... See more keywords