Attenuation of endothelial phosphatidylserine exposure decreases ischemia-reperfusion induced changes in microvascular permeability
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001891
Abstract: BACKGROUND Translocation of phosphatidylserine from the inner leaflet to the outer leaflet of the endothelial membrane via phospholipid scramblase-1 (PLSCR1) is an apoptotic signal responsible for the loss of endothelial barrier integrity after ischemia-reperfusion injury… read more here.
Keywords: reduction; phosphatidylserine exposure; plscr1; ischemia reperfusion ... See more keywords
Wogonoside induces depalmitoylation and translocation of PLSCR1 and N‐RAS in primary acute myeloid leukaemia cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13481
Abstract: Acute myeloid leukaemia (AML) comprises a range of disparate genetic subtypes, involving complex gene mutations and specific molecular alterations. Post‐translational modifications of specific proteins influence their translocation, stability, aggregation and even leading disease progression. Therapies… read more here.
Keywords: myeloid leukaemia; translocation plscr1; translocation; plscr1 ... See more keywords
The Interferon-Inducible Human PLSCR1 Protein Is a Restriction Factor of Human Cytomegalovirus
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01342-21
Abstract: Because several IFN-stimulated genes (ISGs) have been reported to suppress HCMV replication, HCMV replication is thought to be regulated by an IFN-mediated host defense mechanism, but the mechanism remains unclear. PLSCR1 expression is induced in… read more here.
Keywords: expression; ifn; hcmv replication; plscr1 ... See more keywords
Nuclear translocation of PLSCR1 activates STAT1 signaling in basal-like breast cancer
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DOI: 10.7150/thno.43150
Abstract: Rationale: Basal-like breast cancer (BLBC) is associated with high grade, distant metastasis, and poor prognosis; however, the mechanism underlying aggressiveness of BLBC is still unclear. Emerging evidence has suggested that phospholipid scramblase 1 (PLSCR1) is… read more here.
Keywords: blbc; breast cancer; plscr1; cancer ... See more keywords