Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation
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DOI: 10.1038/s41598-018-33851-8
Abstract: Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine proteases, which AAT inhibits, cleave… read more here.
Keywords: degranulation; pltp; kinase; aat ... See more keywords
The role of phospholipid transfer protein in sepsis-associated acute kidney injury
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DOI: 10.1186/s13054-025-05253-6
Abstract: Phospholipid transfer protein (PLTP), a glycoprotein widely expressed in the body, is primarily involved in plasma lipoprotein metabolism. Previous research has demonstrated that PLTP can exert anti-inflammatory effects and improve individual survival in patients with… read more here.
Keywords: pltp lipotransfer; pltp; lipotransfer activity; acute kidney ... See more keywords
DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway
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DOI: 10.1186/s13148-025-01874-4
Abstract: This study aims to elucidate the effect and mechanism of phospholipid transfer protein (PLTP) on vascular dysfunction in DR and explore the molecular mechanism of abnormal PLTP expression based on DNA methylation. Human retinal microvascular… read more here.
Keywords: pltp; akt gsk3; expression; gsk3 ... See more keywords