Potential of the genetically transformed root cultures of Plumbago europaea for biomass and plumbagin production
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Progress"
DOI: 10.1002/btpr.2905
Abstract: Plumbago europaea L. is the main source of plumbagin which is a well‐known pharmacological active compound. In this investigation, genetically transformed roots of P. europaea were obtained by improving some factors affecting the efficiency of… read more here.
Keywords: production; plumbago europaea; biomass; root ... See more keywords
Toxic, cytotoxic and genotoxic effect of plumbagin in the developmental stages of Biomphalaria glabrata (Say, 1818 - intermediate host) and cercaricidal activity against the infectious agent of schistosomiasis mansoni.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.7136
Abstract: BACKGROUND Snails of the genus Biomphalaria spp are intermediate hosts of Schistosoma mansoni, the main etiological agent of schistosomiasis mansoni, which affects about 236,6 million people in tropical and subtropical regions of the world. The… read more here.
Keywords: host; agent schistosomiasis; schistosomiasis mansoni; plumbagin ... See more keywords
Encapsulation of plumbagin using cyclodextrins to enhance plumbagin stability: computational simulation, preparation, characterization, and application
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Inclusion Phenomena and Macrocyclic Chemistry"
DOI: 10.1007/s10847-018-0870-5
Abstract: Encapsulation of plumbagin using cyclodextrins (CDs), including α-cyclodextrin (αCD), β-cyclodextrin (βCD), and γ-cyclodextrin (γCD) to form inclusion complexes was investigated to prevent the loss of plumbagin in pharmaceutical and nutraceutical products. Computational simulations and phase… read more here.
Keywords: using cyclodextrins; plumbagin; encapsulation plumbagin; cyclodextrins enhance ... See more keywords
Differential transcriptome and metabolome analysis of Plumbago zeylanica L. reveal putative genes involved in plumbagin biosynthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104761
Abstract: Plumbagin is a pharmacologically active naphthoquinone present in the Plumbago zeylanica L. having important medicinal properties. The root of P. zeylanica is rich and primary tissue of the plumbagin biosynthesis and accumulation. The complete biosynthetic… read more here.
Keywords: metabolome; zeylanica; plumbagin; plumbagin biosynthesis ... See more keywords
Plumbagin suppresses the human large cell lung cancer cell lines by inhibiting IL‐6/STAT3 signaling in vitro
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.12.021
Abstract: Background: Large cell lung cancer (LCLC) patients have a poor prognosis because their tumors are highly malignant and show resistance to chemotherapy and radiotherapy. Plumbagin has anticancer activity toward several tumor types, but its effects… read more here.
Keywords: plumbagin; cell lung; large cell; cell ... See more keywords
Copper-Plumbagin Complex Produces Potent Anticancer Effects by Depolymerizing Microtubules and Inducing Reactive Oxygen Species and DNA Damage
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c06691
Abstract: Here, we have synthesized a copper complex of plumbagin (Cu-PLN) and investigated its antiproliferative activities in different cancer cells. The crystal structure of Cu-PLN showed that the complex was square planar with a binding stoichiometry… read more here.
Keywords: reactive oxygen; copper; oxygen species; plumbagin ... See more keywords
Development and Validation of HPLC Method for Quantification of Plumbagin in Plumbago Zeylanica L. Roots
Sign Up to like & getrecommendations! Published in 2023 at "Drug Research"
DOI: 10.1055/a-2019-4985
Abstract: Abstract Background An RP-HPLC (Reverse Phase-High-performance liquid chromatography) method for the quantitative estimation and validation of the plumbagin in the methanolic fraction of Plumbago zeylanica L . was developed. Method For achieving good separation, the… read more here.
Keywords: plumbago zeylanica; validation; hplc; hplc method ... See more keywords
Plumbagin inhibits amyloid-&bgr;-induced neurotoxicity: regulation of oxidative stress and nuclear factor erythroid 2-related factor 2 activation
Sign Up to like & getrecommendations! Published in 2018 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001103
Abstract: &bgr;-Amyloid (A&bgr;) species probably exert neurotoxic effects in Alzheimer’s disease. In the present study, the effect of antioxidant plumbagin was tested against A&bgr;25–35-induced neurotoxicity in the SH-SY5Y cell line. Cell viability was determined using an… read more here.
Keywords: bgr; plumbagin; bgr induced; nuclear factor ... See more keywords
Potentiation of antibiotic against Pseudomonas aeruginosa biofilm: a study with plumbagin and gentamicin
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.13476
Abstract: Pseudomonas aeruginosa is one of the fatal biofilm‐forming pathogens which pose to be a problem in clinical infections, contamination of food and marine ecosystems. In this report, a naphthoquinone–plumbagin has been explored for its antimicrobial… read more here.
Keywords: pseudomonas aeruginosa; antibiotic pseudomonas; plumbagin; biofilm ... See more keywords
In vitro antibacterial activity of plumbagin isolated from Plumbago zeylanica L. against methicillin‐resistant Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2019 at "Letters in Applied Microbiology"
DOI: 10.1111/lam.13160
Abstract: Plumbagin (5‐hydroxy‐2‐methyl‐1,4‐napthoquinone) is a bicyclic naphthoquinone, found in three major plant families viz. Plumbaginaceae, Ebenceae and Droseraceae. The phytochemical is reported to exhibit various pharmacological properties. In this study, plumbagin isolated from Plumbago zeylanica L.… read more here.
Keywords: plumbagin isolated; plumbagin; activity plumbagin; mrsa ... See more keywords
Nanoincorporation of Plumbagin in Micelles Increase Its in Vivo Anti-Plasmodial Properties
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Parasitology"
DOI: 10.18502/ijpa.v17i2.9538
Abstract: Background: The application of plumbagin (PLN), with a wide use in pharmaceutical science, is limited due to its low water solubility and poor bioavailability. Micelles can encapsulate hydrophobic drugs due to their hydrophobic core. The… read more here.
Keywords: anti plasmodial; vivo anti; drug; plumbagin ... See more keywords