Podocalyxin‐Like Protein 1 Regulates Pluripotency through the Cholesterol Biosynthesis Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205451
Abstract: Deciphering signaling mechanisms critical for the extended pluripotent stem cell (EPSC) state and primed pluripotency is necessary for understanding embryonic development. Here, a membrane protein, podocalyxin‐like protein 1 (PODXL) as being essential for extended and… read more here.
Keywords: podxl; pluripotency; like protein; podocalyxin like ... See more keywords
Purification of pluripotent embryonic stem cells using dielectrophoresis and a flow control system
Sign Up to like & getrecommendations! Published in 2022 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202100113
Abstract: Pluripotent stem cells (PSCs) such as embryonic stem cells and induced PSCs can differentiate into all somatic cell types such as cardiomyocytes, nerve cells, and chondrocytes. However, PSCs can easily lose their pluripotency if the… read more here.
Keywords: flow control; embryonic stem; control system; pluripotency ... See more keywords
Disrupting Interactions Between β‐Catenin and Activating TCFs Reconstitutes Ground State Pluripotency in Mouse Embryonic Stem Cells
Sign Up to like & getrecommendations! Published in 2017 at "STEM CELLS"
DOI: 10.1002/stem.2647
Abstract: The 2i‐media, composed of two small molecule inhibitors (PD0325901 and CHIR99021) against MEK and GSK3‐kinases, respectively, is known to establish naïve ground state pluripotency in mouse embryonic stem cells (mESCs). These inhibitors block MEK‐mediated differentiation,… read more here.
Keywords: state; stem cells; pluripotency; state pluripotency ... See more keywords
ESRP1‐Induced CD44 v3 Is Important for Controlling Pluripotency in Human Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2864
Abstract: The importance of alternative splicing (AS) events in pluripotency regulation has been highlighted by the determination of different roles and contributions of different splice isoforms of pluripotency‐related genes and by the identification of distinct pluripotency‐related… read more here.
Keywords: esrp1; human pluripotent; pluripotency; cd44 ... See more keywords
Pluripotency Stemness and Cancer: More Questions than Answers.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2021_663
Abstract: Embryonic stem cells and induced pluripotent stem cells provided us with fascinating new knowledge in recent years. Mechanistic insight into intricate regulatory circuitry governing pluripotency stemness and disclosing parallels between pluripotency stemness and cancer instigated… read more here.
Keywords: cancer; pluripotency; pluripotency stemness; stem cells ... See more keywords
Induction of Human Naïve Pluripotency Using Chemical Resetting.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1908-7_3
Abstract: Human pluripotent stem cells exist in naïve and primed states that recapitulate the distinct molecular and cellular properties of pre- and post-implantation epiblast cells, respectively. Naïve pluripotent stem cells can be captured directly from blastocysts… read more here.
Keywords: chemical resetting; primed cells; stem cells; pluripotent stem ... See more keywords
In Vivo Transient and Partial Cell Reprogramming to Pluripotency as a Therapeutic Tool for Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0888-0
Abstract: In theory, human diseases in which a specific cell type degenerates, such as neurodegenerative diseases, can be therapeutically addressed by replacement of the lost cells. The classical strategy for cell replacement is exogenous cell transplantation,… read more here.
Keywords: vivo transient; neurodegenerative diseases; pluripotency; partial cell ... See more keywords
ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency
Sign Up to like & getrecommendations! Published in 2020 at "Protein & Cell"
DOI: 10.1007/s13238-020-00775-x
Abstract: Cell-fate decisions are governed by comprehensive generegulatory programs. During the preimplantation development, at least two waves of cell fate decisions are made while the cells gradually lose their totipotency (Schrode et al., 2013). The first… read more here.
Keywords: escs; zfp281; pluripotency; stem ... See more keywords
Determining Osteogenic Differentiation Efficacy of Pluripotent Stem Cells by Telomerase Activity
Sign Up to like & getrecommendations! Published in 2018 at "Tissue Engineering and Regenerative Medicine"
DOI: 10.1007/s13770-018-0138-6
Abstract: Background:Bone tissue engineering based on pluripotent stem cells (PSCs) is a new approach to deal with bone defects. Protocols have been developed to generate osteoblasts from PSCs. However, the low efficiency of this process is… read more here.
Keywords: telomerase activity; efficacy; pluripotency; differentiation ... See more keywords
Application of amphiphilic fluorophore-derived nanoparticles to provide contrast to human embryonic stem cells without affecting their pluripotency and to monitor their differentiation into neuron-like cells.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.07.051
Abstract: Fluorogenic labeling is a potential technique in biology that allows for direct detection and tracking of cells undergoing various biological processes. Compared to traditional genetic modification approaches, labeling cells with nanoparticles has advantages, especially for… read more here.
Keywords: hes cells; pluripotency; differentiation; embryonic stem ... See more keywords
AMPK activators contribute to maintain naïve pluripotency in mouse embryonic stem cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.164
Abstract: Pluripotent stem cells retain the property to self-renew and differentiate into all cell types under defined conditions. Among mouse embryonic stem cells (ESCs), which are pluripotent but heterogenous in gene expression and morphology, an ESC… read more here.
Keywords: pluripotency; mouse embryonic; embryonic stem; stem cells ... See more keywords