Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception.
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DOI: 10.1073/pnas.2215155120
Abstract: Chemistry-alone approach has recently been applied for incepting pluripotency in somatic cells, representing a breakthrough in biology. However, chemical reprogramming is hampered by low efficiency, and the underlying molecular mechanisms remain unclear. Particularly, chemical compounds… read more here.
Keywords: transcription; pluripotency; rna exosome; small molecules ... See more keywords