Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2017.03.023
Abstract: Summary The core pluripotency transcription factor NANOG is critical for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Although NANOG is phosphorylated at multiple residues, the role of NANOG phosphorylation in ESC self-renewal is… read more here.
Keywords: pluripotency; context dependent; nanog phosphorylation; pluripotency reprogramming ... See more keywords
Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2
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DOI: 10.1038/s41467-019-11054-7
Abstract: Oct4, along with Sox2 and Klf4 (SK), can induce pluripotency but structurally similar factors like Oct6 cannot. To decode why Oct4 has this unique ability, we compare Oct4-binding, accessibility patterns and transcriptional waves with Oct6… read more here.
Keywords: pluripotency; oct4 sox2; chromatin opening; pluripotency reprogramming ... See more keywords
27 Quisinostat, a Potent Histone Deacetylase Inhibitor, Regulates the Expression of Pluripotency- and Reprogramming-Related Genes on Somatic Cell Nuclear Transferred Porcine Embryos
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DOI: 10.1071/rdv30n1ab27
Abstract: The low efficiency of somatic cell nuclear transfer (SCNT) has been attributed mostly to inefficient epigenetic reprogramming. Recently, various histone deacetylase inhibitors (HDACi) were used to improve developmental competence of SCNT embryos in several species.… read more here.
Keywords: 100 jnj; embryos; jnj; pluripotency reprogramming ... See more keywords