A Susceptibility Locus on Chromosome 13 Profoundly Impacts the Stability of Genomic Imprinting in Mouse Pluripotent Stem Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.073
Abstract: Cultured pluripotent cells accumulate detrimental chromatin alterations, including DNA methylation changes at imprinted genes known as loss of imprinting (LOI). Although the occurrence of LOI is considered a stochastic phenomenon, here we document a genetic… read more here.
Keywords: susceptibility locus; mouse pluripotent; pluripotent cells; chromosome ... See more keywords
The Epigenetic Paradox of Pluripotent ES Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2016.12.009
Abstract: The propagation and maintenance of gene expression programs are at the foundation of the preservation of cell identity. A large and complex set of epigenetic mechanisms enables the long-term stability and inheritance of transcription states.… read more here.
Keywords: pluripotent cells; epigenetic paradox; paradox pluripotent; epigenetic regulation ... See more keywords
Insights into the Establishment of Chromatin States in Pluripotent Cells from Studies of X Inactivation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.03.013
Abstract: Animal development entails the sequential and coordinated specialization of cells. During cell differentiation, transcription factors, cell signaling pathways, and chromatin-associated protein complexes cooperate in regulating the expression of a large number of genes. Here, we… read more here.
Keywords: chromatin states; pluripotent cells; states pluripotent; insights establishment ... See more keywords
Pluripotent cells display enhanced resistance to mutagenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Stem cell research"
DOI: 10.1016/j.scr.2016.12.029
Abstract: Pluripotent cells have been reported to exhibit lower frequencies of point mutations and higher levels of DNA repair than differentiated cells. This predicts that pluripotent cells are less susceptible to mutagenic exposures than differentiated cells.… read more here.
Keywords: pluripotent cells; point mutations; pluripotent; cells display ... See more keywords
Active turnover of genomic methylcytosine in pluripotent cells
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DOI: 10.1038/s41589-020-0621-y
Abstract: Epigenetic plasticity underpins cell potency, but the extent to which active turnover of DNA methylation contributes to such plasticity is not known, and the underlying pathways are poorly understood. Here we use metabolic labeling with… read more here.
Keywords: pluripotent cells; oxidation; turnover; active turnover ... See more keywords
Stemness of Human Pluripotent Cells: Hypoxia-Like Response Induced by Low Nitric Oxide
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DOI: 10.3390/antiox10091408
Abstract: The optimization of conditions to promote the stemness of pluripotent cells in vitro is instrumental for their use in advanced therapies. We show here that exposure of human iPSCs and human ESCs to low concentrations… read more here.
Keywords: pluripotent cells; cells hypoxia; human pluripotent; response ... See more keywords