Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22201-4
Abstract: The transition from naive to primed pluripotency is accompanied by an extensive reorganisation of transcriptional and epigenetic programmes. However, the role of transcriptional enhancers and three-dimensional chromatin organisation in coordinating these developmental programmes remains incompletely… read more here.
Keywords: human pluripotent; pluripotent states; pluripotent; gene regulatory ... See more keywords
Distinct transcription kinetics of pluripotent cell states
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Systems Biology"
DOI: 10.15252/msb.202110407
Abstract: Mouse embryonic stem cells (mESCs) can adopt naïve, ground, and paused pluripotent states that give rise to unique transcriptomes. Here, we use transient transcriptome sequencing (TT‐seq) to define both coding and non‐coding transcription units (TUs)… read more here.
Keywords: pluripotent states; state; genome wide; transcription ... See more keywords
The Divergent Pluripotent States in Mouse and Human Cells
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13081459
Abstract: Pluripotent stem cells (PSCs), which can self-renew and give rise to all cell types in all three germ layers, have great potential in regenerative medicine. Recent studies have shown that PSCs can have three distinct… read more here.
Keywords: medicine; divergent pluripotent; human cells; mouse human ... See more keywords