Feeder cells treated with ethanol can be used to maintain self‐renewal and pluripotency of human pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13538
Abstract: Feeder cells play an important role in the culture of human pluripotent stem cells (hPSCs) in vitro. Previously, we used methanol as a fixative to prepare feeder cells for the cultivation of pluripotent stem cells (PSCs),… read more here.
Keywords: pluripotent stem; self renewal; feeder cells; cells treated ... See more keywords
Engineering of Mature Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Using Substrates with Multiscale Topography
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DOI: 10.1002/adfm.201707378
Abstract: Producing mature and functional cardiomyocytes (CMs) by in vitro differentiation of induced pluripotent stem cells (iPSCs) using only biochemical cues is challenging. To mimic the biophysical and biomechanical complexity of the native in vivo environment… read more here.
Keywords: topography; mature; pluripotent stem; induced pluripotent ... See more keywords
Thermoresponsive Hydrogels as Microniches for Growth and Controlled Release of Induced Pluripotent Stem Cells
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DOI: 10.1002/adfm.202010630
Abstract: The recently emerging stem‐cell artificial niche engineering in induced pluripotent stem cell (iPSCs) 3D cultures has provided enormous opportunities to fully utilize the potential of these cells in biomedical applications. Although a fully chemically defined… read more here.
Keywords: controlled release; niche; induced pluripotent; pluripotent stem ... See more keywords
Optimized Lipid Nanoparticles Delivery Enables Efficient Circular RNA‐Mediated Forward Programming and Lineage Specification of Induced Pluripotent Stem Cells
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DOI: 10.1002/adfm.202520042
Abstract: Directed differentiation of induced pluripotent stem cells (iPSCs) into functionally mature hepatocytes holds great potential for liver regeneration. However, current multi‐step protocols are inefficient and often fail to generate fully functional cells. In this study,… read more here.
Keywords: delivery; stem; pluripotent stem; stem cells ... See more keywords
Cellular Alignment and Matrix Stiffening Induced Changes in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
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DOI: 10.1002/adhm.202402228
Abstract: Biological processes are inherently dynamic, necessitating biomaterial platforms capable of spatiotemporal control over cellular organization and matrix stiffness for accurate study of tissue development, wound healing, and disease. However, most in vitro platforms remain static.… read more here.
Keywords: matrix; pluripotent stem; cell; human induced ... See more keywords
Tapered Pillar Design for High‐Precision Force Readout in Miniaturized Engineered Heart Tissues From Human Pluripotent Stem Cells
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DOI: 10.1002/adhm.202501664
Abstract: Engineered heart tissues (EHTs) formed around flexible pillars are used to measure the contraction force of myocytes. When based on cardiac cells derived from human induced pluripotent stem cells (hiPSCs), EHTs capture human cardiac physiology… read more here.
Keywords: force; engineered heart; pluripotent stem; stem cells ... See more keywords
Long‐Term Culture of Human Pluripotent Stem Cells in Xeno‐Free Condition Using Functional Polymer Films
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202403952
Abstract: Human pluripotent stem cells (hPSCs), encompassing human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), hold immense potential in regenerative medicine, offering new opportunities for personalized cell therapies. However, their clinical translation… read more here.
Keywords: xeno free; stem; pluripotent stem; culture ... See more keywords
Investigating and Resolving Cardiotoxicity Induced by COVID‐19 Treatments using Human Pluripotent Stem Cell‐Derived Cardiomyocytes and Engineered Heart Tissues
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203388
Abstract: Coronavirus disease 2019 continues to spread worldwide. Given the urgent need for effective treatments, many clinical trials are ongoing through repurposing approved drugs. However, clinical data regarding the cardiotoxicity of these drugs are limited. Human… read more here.
Keywords: cell; stem cell; pluripotent stem; human pluripotent ... See more keywords
Symmetry Breaking of Human Pluripotent Stem Cells (hPSCs) in Micropattern Generates a Polarized Spinal Cord-Like Organoid (pSCO) with Dorsoventral Organization.
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DOI: 10.1002/advs.202301787
Abstract: Axis formation and related spatial patterning are initiated by symmetry breaking during development. A geometrically confined culture of human pluripotent stem cells (hPSCs) mimics symmetry breaking and cell patterning. Using this, polarized spinal cord organoids… read more here.
Keywords: pluripotent stem; human pluripotent; spinal cord; symmetry breaking ... See more keywords
Recent insights from human induced pluripotent stem cell models into the role of microglia in amyotrophic lateral sclerosis
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DOI: 10.1002/bies.202400054
Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, primarily leading to the degeneration of motor neurons. The traditional focus on motor neuron‐centric mechanisms has recently shifted towards understanding the contribution of non‐neuronal cells, such as… read more here.
Keywords: role; stem cell; pluripotent stem; amyotrophic lateral ... See more keywords
A brief chronicle of research on human pluripotent stem cells
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DOI: 10.1002/bies.202400092
Abstract: Today, human pluripotent stem cell technologies find widespread application across biomedical research, as models for early human development, as platforms for functional human genomics, as tools for the study of disease, drug screening and toxicology,… read more here.
Keywords: pluripotent stem; biology; human pluripotent; cell ... See more keywords