Economic Evaluation of Talimogene Laherparepvec Plus Ipilimumab Combination Therapy vs Ipilimumab Monotherapy in Patients With Advanced Unresectable Melanoma
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2018.3958
Abstract: Importance A phase 2 trial comparing talimogene laherparepvec plus ipilimumab vs ipilimumab monotherapy in patients with advanced unresectable melanoma found no differential benefit in progression-free survival (PFS) but noted objective response rates (ORRs) of 38.8%… read more here.
Keywords: talimogene laherparepvec; life; laherparepvec plus; plus ipilimumab ... See more keywords
First-line Nivolumab Plus Ipilimumab vs Sunitinib for Metastatic Renal Cell Carcinoma: A Cost-effectiveness Analysis
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2018.7086
Abstract: Importance Recently, new drugs have been approved for the first-line treatment of metastatic renal cell carcinoma (mRCC). Nivolumab plus ipilimumab significantly increases overall survival for intermediate- and poor-risk patients with mRCC. However, considering the high… read more here.
Keywords: first line; sunitinib; nivolumab plus; plus ipilimumab ... See more keywords
Association of Body Mass Index With the Safety Profile of Nivolumab With or Without Ipilimumab.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.5409
Abstract: Importance Increased survival with immune checkpoint inhibitors has been reported for patients with obesity vs a normal body mass index (BMI). However, the association of obesity with the safety of immune checkpoint inhibitors warrants study.… read more here.
Keywords: nivolumab plus; patients obesity; plus ipilimumab; grade iraes ... See more keywords
First-line nivolumab + ipilimumab in advanced NSCLC: CheckMate 227 subpopulation analyses in Asian patients
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DOI: 10.1016/j.esmoop.2022.100394
Abstract: Background Nivolumab plus ipilimumab demonstrated clinically meaningful improvement in efficacy versus chemotherapy with a manageable safety profile in patients with advanced non-small cell lung cancer (NSCLC) and tumor programmed death-ligand 1 (PD-L1) expression ≥1% or read more here.
Keywords: nivolumab plus; chemotherapy; plus ipilimumab; checkmate 227 ... See more keywords
Re: Nivolumab plus Ipilimumab Versus Sunitinib in Advanced Renal-cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "European urology"
DOI: 10.1016/j.eururo.2018.07.019
Abstract: Expert's summary: Checkmate 214 is a randomised trial comparing the immune checkpoint inhibitors (ICIs) ipilimumab and nivolumab (IN) in combination with sunitinib in previously untreated metastatic renal cell carcinoma (mRCC). The results showed significantly better… read more here.
Keywords: cell carcinoma; renal cell; nivolumab plus; plus ipilimumab ... See more keywords
First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial
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DOI: 10.1016/s0140-6736(20)32714-8
Abstract: BACKGROUND Approved systemic treatments for malignant pleural mesothelioma (MPM) have been limited to chemotherapy regimens that have moderate survival benefit with poor outcomes. Nivolumab plus ipilimumab has shown clinical benefit in other tumour types, including… read more here.
Keywords: chemotherapy; malignant pleural; plus ipilimumab; group ... See more keywords
Nivolumab plus ipilimumab in malignant pleural mesothelioma
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2022.2102482
Abstract: ABSTRACT Introduction Unresectable pleural mesothelioma is a poor prognosis disease. Improvement in overall survival (OS) has been shown with PEMETREXED combined with CISPLATIN. BEVACIZUMAB combined with chemotherapy is associated with an improvement in OS, compared… read more here.
Keywords: malignant pleural; pleural mesothelioma; mesothelioma; ipilimumab malignant ... See more keywords
Immune-related adverse events are clinical biomarkers to predict favorable outcomes in advanced renal cell carcinoma treated with nivolumab plus ipilimumab.
Sign Up to like & getrecommendations! Published in 2022 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyac009
Abstract: BACKGROUND Immune checkpoint inhibitors cause various immune-related adverse events. The present study examined the association between the incidence of immune-related adverse events and survival outcomes in patients treated with nivolumab plus ipilimumab for patients with… read more here.
Keywords: immune related; related adverse; nivolumab plus; adverse events ... See more keywords
Real-world effectiveness of nivolumab plus ipilimumab and second-line therapy in Japanese untreated patients with metastatic renal cell carcinoma: 2-year analysis from a multicenter retrospective clinical study (J-cardinal study)
Sign Up to like & getrecommendations! Published in 2022 at "Japanese Journal of Clinical Oncology"
DOI: 10.1093/jjco/hyac124
Abstract: Abstract Background Nivolumab plus ipilimumab combination therapy is one of the standard therapies for untreated renal cell carcinoma patients with an International Metastatic Renal Cell Carcinoma Database Consortium intermediate/poor risk. We have previously reported the… read more here.
Keywords: cell carcinoma; renal cell; therapy; nivolumab plus ... See more keywords
Biomarker analysis from CheckMate 214: nivolumab plus ipilimumab versus sunitinib in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004316
Abstract: Background The phase 3 CheckMate 214 trial demonstrated higher response rates and improved overall survival with nivolumab plus ipilimumab versus sunitinib in first-line therapy for advanced clear-cell renal cell carcinoma (RCC). An unmet need exists… read more here.
Keywords: checkmate 214; ipilimumab versus; nivolumab plus; plus ipilimumab ... See more keywords
FRACTION-RCC: nivolumab plus ipilimumab for advanced renal cell carcinoma after progression on immuno-oncology therapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005780
Abstract: Background The role and sequencing of combination immuno-oncology (IO) therapy following progression on or after first-line IO therapy has not been well-established. The Fast Real-time Assessment of Combination Therapies in Immuno-ONcology (FRACTION) program is an… read more here.
Keywords: oncology; progression; therapy; immuno oncology ... See more keywords