SJP-L-5 inhibits HIV-1 polypurine tract primed plus-strand DNA elongation, indicating viral DNA synthesis initiation at multiple sites under drug pressure
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20954-5
Abstract: In a previous study the small molecule SJP-L-5 that inhibits HIV replication, has been shown to block uncoating of the viral capsid. Continued study showed that SJP-L-5 might hinder HIV capsid uncoating by blocking the… read more here.
Keywords: dna synthesis; dna; strand dna; plus strand ... See more keywords
Dynamics and consequences of the HTLV-1 proviral plus-strand burst
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DOI: 10.1101/2022.08.01.502260
Abstract: Expression of the transcriptional transactivator protein Tax, encoded on the proviral plus-strand of human T-cell leukaemia virus type 1 (HTLV-1), is crucial for the replication of the virus, but Tax-expressing cells are rarely detected in… read more here.
Keywords: plus strand; tax expression; cell; tax ... See more keywords
Spontaneous HTLV-1 transcription is accompanied by distinct epigenetic changes in the 5' and 3' long terminal repeats.
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DOI: 10.12688/wellcomeopenres.14741.1
Abstract: Background: The human retrovirus HTLV-1 inserts the viral complementary DNA of 9 kb into the host genome. Both plus- and minus-strands of the provirus are transcribed, respectively from the 5' and 3' long terminal repeats… read more here.
Keywords: htlv; transcription; tax; epigenetic modifications ... See more keywords
Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies
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DOI: 10.1371/journal.pcbi.1010423
Abstract: Plus-strand RNA viruses are the largest group of viruses. Many are human pathogens that inflict a socio-economic burden. Interestingly, plus-strand RNA viruses share remarkable similarities in their replication. A hallmark of plus-strand RNA viruses is… read more here.
Keywords: plus strand; replication; rna; virus ... See more keywords
HTLV-1: Regulating the Balance Between Proviral Latency and Reactivation
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DOI: 10.3389/fmicb.2018.00449
Abstract: HTLV-1 plus-strand transcription begins with the production of doubly-spliced tax/rex transcripts, the levels of which are usually undetectable in freshly isolated peripheral blood mononuclear cells (PBMCs) from HTLV-1-infected individuals. However, the presence of a sustained… read more here.
Keywords: htlv; latency; reactivation; plus strand ... See more keywords