Tailoring structural properties of spray-dried methotrexate-loaded poly (lactic acid)/poloxamer microparticle blends
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DOI: 10.1007/s10856-018-6214-6
Abstract: AbstractDrug delivery systems can overcome cancer drug resistance, improving the efficacy of chemotherapy agents. Poly (lactic acid) (PLA) microparticles are an interesting alternative because their hydrophobic surface and small particle size could facilitate interactions with… read more here.
Keywords: poly lactic; drug; spray dried; plx ... See more keywords
Drug Solubilization by Means of Partition/Association Equilibrium Using a Modified Nanosized Dendrimeric Biopolymer
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DOI: 10.1208/s12249-019-1490-0
Abstract: The objective of this study is to elucidate the combined effects of a novel type of material being investigated as a new excipient, an octenylsuccinate-modified dendrimer-like biopolymer (OS-DLB) and poloxamer (PLX), on the solubility of poorly… read more here.
Keywords: biopolymer; drug; solubilization; drug solubilization ... See more keywords
Highly Water-Soluble Solid Dispersions of Honokiol: Preparation, Solubility, and Bioavailability Studies and Anti-Tumor Activity Evaluation
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DOI: 10.3390/pharmaceutics11110573
Abstract: Honokiol (HK), a well-tolerated natural product, has many multiple pharmacological activities. However, its poor water solubility and low bioavailability limit its clinical application and development. The aim of this research was to prepare the solid… read more here.
Keywords: highly water; bioavailability; solid dispersions; solubility ... See more keywords