PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.3c01775
Abstract: Targeting microtubules is the most effective wide-spectrum pharmacological strategy in antitumoral chemotherapy, and current research focuses on reducing main drawbacks: neurotoxicity and resistance. PM534 is a novel synthetic compound derived from the Structure–Activity-Relationship study on… read more here.
Keywords: pm534; colchicine; target protein; optimized target ... See more keywords
Abstract 6239: PM534 is a novel microtubule-destabilizing agent with high affinity and potent antineoplastic properties
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6239
Abstract: Background: Microtubule targeting compounds are a successful class of anticancer agents in the clinic. Although highly potent, the currently approved antitumor agents targeting tubulin present some drawbacks such as the development of acquired resistances, which… read more here.
Keywords: microtubule destabilizing; high affinity; affinity; novel microtubule ... See more keywords