Polymyxin B-Polysaccharide Polyion Nanocomplex with Improved Biocompatibility and Unaffected Antibacterial Activity for Acute Lung Infection Management.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201901542
Abstract: The decade-old antibiotic, polymyxin B (PMB), is regarded as the last line defense against gram-negative "superbug." However, the serious nephrotoxicity and neurotoxicity strongly obstruct further application of this highly effective antibiotic. Herein, a charge switchable… read more here.
Keywords: antibacterial activity; pmb; polyion nanocomplex; acute lung ... See more keywords
Polymyxin B exerts nephrotoxicity effects via inhibition of the Nrf2/NQO1 pathway-mediated antioxidant response.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23344
Abstract: Polymyxin B (PMB) is a polypeptide antibiotic widely used in treating multidrug‐resistant Gram‐negative bacteria. However, nephrotoxicity is a serious adverse effect that limits its clinical use. Therefore, clarification of the molecular mechanism of PMB‐induced renal… read more here.
Keywords: nrf2 nqo1; nqo1 pathway; pmb; pmb induced ... See more keywords
Dewaterability enhancement and heavy metals immobilization by pig manure biochar addition during hydrothermal treatment of sewage sludge
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-019-04961-1
Abstract: Hydrothermal treatment (HTT) of sewage sludge (SS) with pig manure biochar (PMB) addition at 160–200 °C was conducted in this study. The effects of PMB addition on the dewaterability of SS and the speciation evolution, leaching… read more here.
Keywords: addition; hydrothermal treatment; heavy metals; pmb ... See more keywords
Comparative evaluation of wheat straw and press mud biochars for Cr(VI) elimination from contaminated aqueous solution
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Technology and Innovation"
DOI: 10.1016/j.eti.2020.101017
Abstract: Abstract Chromium (Cr(VI)) presence in aqueous systems has become a worldwide health and environmental concern. Here, we compared and explored the Cr(VI) removal potential of novel biochars produced from wheat straw and press mud in… read more here.
Keywords: press mud; sorption; pmb; wheat straw ... See more keywords
Development of the Philippine Mobile Belt in northern Luzon from Eocene to Pliocene
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Asian Earth Sciences"
DOI: 10.1016/j.jseaes.2016.08.018
Abstract: Abstract The origin of the Philippine Archipelago is characterized by the combination of the oceanic Philippine Mobile Belt (PMB) and the Palawan Continental Block (PCB). This paper is focused on the geologic evolution of the… read more here.
Keywords: eocene; northern luzon; pliocene; pmb ... See more keywords
Erythro-PmBs: A Selective Polymyxin B Delivery System Using Antibody-Conjugated Hybrid Erythrocyte Liposomes.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00017
Abstract: As a result of the growing worldwide antibiotic resistance crisis, many currently existing antibiotics have become ineffective due to bacteria developing resistive mechanisms. There are a limited number of potent antibiotics that are successful at… read more here.
Keywords: erythrocyte liposomes; hybrid erythrocyte; erythro pmbs; pmb ... See more keywords
An inflammation-targeted nanoparticle with bacteria forced release of polymyxin B for pneumonia therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr02026b
Abstract: The epidemic of multidrug-resistant Gram-negative bacteria is an ever-growing global concern. Polymyxin B (PMB), a kind of "old fashioned" antibiotic, has been revived in clinical practice and mainly used as last-line antibiotics for otherwise untreatable… read more here.
Keywords: inflammation; nanoparticle; pneumonia; pmb ... See more keywords
Is routine adnexal scanning for postmenopausal bleeding of value? Observational study of 2101 women
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Obstetrics and Gynaecology"
DOI: 10.1080/01443615.2017.1306031
Abstract: Abstract Our objective is to assess the merits of adnexal scanning during the investigation of women with postmenopausal bleeding (PMB) in terms of adnexal cancer diagnosis. This observational study was designed utilising an institutional PMB… read more here.
Keywords: observational study; routine adnexal; pmb; postmenopausal bleeding ... See more keywords
Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration
Sign Up to like & getrecommendations! Published in 2021 at "Drug Delivery"
DOI: 10.1080/10717544.2020.1870021
Abstract: Abstract In relieving local pains, lidocaine, one of ester-type local anesthetics, has been used. To develop the lidocaine membranes of enhanced local anesthetic effects, we have designed to establish the composition of wound dressings based… read more here.
Keywords: wound healing; regeneration; tissue; pmb ... See more keywords
Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of Achromobacter Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03729-22
Abstract: Achromobacter species can cause chronic and potentially severe infections in immunocompromised patients, especially in those with cystic fibrosis. Bacteria cannot be eradicated due to Achromobacter's intrinsic multidrug resistance. ABSTRACT The Achromobacter genus includes opportunistic pathogens… read more here.
Keywords: clinical isolates; pmb; resistance; achromobacter species ... See more keywords
Ancillary PanoMap OCT shows the progression of glaucomatous papillomacular bundle defect with disc haemorrhage on the fovea–disc axis
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Ophthalmology"
DOI: 10.1136/bjo-2021-320642
Abstract: Background/aims To identify the spatial relationship between disc haemorrhage (DH) on the fovea–disc axis and retinal nerve fibre layer (RNFL) defect in the papillomacular bundle (PMB) using ancillary PanoMap optical coherence tomography (OCT). Methods We… read more here.
Keywords: progression; fovea disc; pmb; pmb defects ... See more keywords