Polymyxin B exerts nephrotoxicity effects via inhibition of the Nrf2/NQO1 pathway-mediated antioxidant response.
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DOI: 10.1002/jbt.23344
Abstract: Polymyxin B (PMB) is a polypeptide antibiotic widely used in treating multidrug‐resistant Gram‐negative bacteria. However, nephrotoxicity is a serious adverse effect that limits its clinical use. Therefore, clarification of the molecular mechanism of PMB‐induced renal… read more here.
Keywords: nrf2 nqo1; nqo1 pathway; pmb; pmb induced ... See more keywords