Primary mediastinal large B‐cell lymphoma is characterized by large‐scale copy‐neutral loss of heterozygosity
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23069
Abstract: Development of primary mediastinal B‐cell lymphoma (PMBL) is driven by cumulative genomic aberrations. We discovered a unique copy‐neutral loss of heterozygosity (CN‐LOH) landscape of PMBL which distinguishes this tumor from other B‐cell malignancies, including the… read more here.
Keywords: pmbl; cell; cell lymphoma; large cell ... See more keywords
Combined PD-1 and JAK1/2 inhibition in refractory primary mediastinal B-cell lymphoma
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DOI: 10.1007/s00277-018-3233-9
Abstract: Dear Editor, Primarymediastinal large B-cell lymphoma (PMBL) represents 2–4% of all B-cell non-Hodgkin lymphoma [1]. It shares clinical and molecular features with classical Hodgkin lymphoma [2]. Amplification or gain of 9p24.1 is observed in more… read more here.
Keywords: lymphoma; pmbl; cell lymphoma; refractory ... See more keywords
The utility of CD83, fascin and CD23 in the differential diagnosis of primary mediastinal large B-cell lymphoma versus classic Hodgkin lymphoma.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2019.04.009
Abstract: Primary mediastinal large B-cell lymphoma (PMBL) and classic Hodgkin lymphoma (CHL) are the most common large cell lymphomas arising in the mediastinum and are thought to be closely related histogenetically. Although the distinction between PMBL… read more here.
Keywords: lymphoma; cd83 fascin; pmbl; gzl ... See more keywords
EBV-Positive Primary Large B-cell Lymphoma: Highlighting the Role of XPO1 in the Diagnosis of Mediastinal Lymphomas
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DOI: 10.1093/ajcp/aqz121.010
Abstract: Primary mediastinal (thymic) large B-cell lymphoma (PMBL) is described to be almost always negative for EBV in the current WHO. In the context of a mediastinal lymphoma, the distinction between PMBL, classic Hodgkin lymphoma (CHL),… read more here.
Keywords: lymphoma; pmbl; diagnosis; ebv positive ... See more keywords
Diagnostic utility of programmed cell death ligand 1 (clone SP142) in mediastinal composite lymphoma: A report of two cases
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DOI: 10.1111/pin.12891
Abstract: Composite lymphoma is a well‐known diagnostic entity exhibiting the synchronous occurrence of two or more distinct types of lymphomas in the same specimen. Here we report two patients, a 14‐year‐old female (Case 1) and a… read more here.
Keywords: pmbl; report two; case; composite lymphoma ... See more keywords
Abstract 2381: Blinatumomab enhanced anti-tumor activity against rituximab sensitive and resistant Burkitt Lymphoma (BL) and Primary Mediastinal B-cell Lymphoma (PMBL)
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-2381
Abstract: Background: Childhood, Adolescent and Young Adult (CAYA) B-NHL represents the third most common malignancies in children under the age of 15yrs (Hochberg/Cairo et al, BJH 2009; Miles/Cairo, BJH. 2012).The prognosis of mature-B-NHL (which include BL/PMBL)… read more here.
Keywords: blinatumomab; cairo; activity; lymphoma ... See more keywords
Polatuzumab Vedotin, an Antibody-Drug Conjugate Targeting CD79b, Is a Highly Active Agent Against Burkitt Lymphoma and Primary Mediastinal B-Cell Lymphoma
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DOI: 10.1182/blood-2019-128580
Abstract: Introduction Mature B-cell lymphoma (MBL) accounts for approximately 60% of all non-Hodgkin lymphoma (NHL) in children and adolescents (Cairo et al, Blood, 2007). MBL in children and adolescents is comprised of approximately 75-80% Burkitt lymphoma… read more here.
Keywords: lymphoma; pmbl; children adolescents; cairo ... See more keywords
Characterization of DLBCL with a PMBL gene expression signature.
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DOI: 10.1182/blood.2020007683
Abstract: Primary mediastinal large B-cell lymphoma (PMBL) is a type of aggressive B-cell lymphoma that typically affects young adults, characterized by presence of a bulky anterior mediastinal mass. Lymphomas with gene expression features of PMBL have… read more here.
Keywords: dlbcl; pmbl; gene expression; gene ... See more keywords
Polatuzumab Vedotin Alone or in Combination with Obinutuzumab Synergistically Enhances In-Vitro Cytotoxicity and Cytokine Release Against CD20+/ CD79b+ Burkitt Lymphoma (BL) /Primary Mediastinal Large B Cell Lymphoma (PMBL)
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.1540.1540
Abstract: Background: Pediatric Burkitt Lymphoma (PBL) represents the most common malignancy in childhood and adolescent non-Hodgkin Lymphoma (NHL) but occurs in less than 5% of adult NHL cases (Hochberg/Cairo et al, BJH 2009; Miles/Cairo, BJH. 2012).… read more here.
Keywords: lymphoma; pmbl; cytotoxicity; cairo ... See more keywords