MHC Molecules, T cell Receptors, Natural Killer Cell Receptors, and Viral Immunoevasins-Key Elements of Adaptive and Innate Immunity.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9367-9_2
Abstract: Molecules encoded by the Major Histocompatibility Complex (MHC) bind self or foreign peptides and display these at the cell surface for recognition by receptors on T lymphocytes (designated T cell receptors-TCR) or on natural killer… read more here.
Keywords: mhc molecules; natural killer; cell receptors; mhc ... See more keywords
A TCR mechanotransduction signaling loop induces negative selection in the thymus
Sign Up to like & getrecommendations! Published in 2018 at "Nature Immunology"
DOI: 10.1038/s41590-018-0259-z
Abstract: The T cell antigen receptor (TCR) expressed on thymocytes interacts with self-peptide major histocompatibility complex (pMHC) ligands to signal apoptosis or survival. Here, we found that negative-selection ligands induced thymocytes to exert forces on the… read more here.
Keywords: negative selection; selection; pmhc cd8; pmhc ... See more keywords
Development of a PRAME pMHC targeted T cell engager for solid tumor therapy
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DOI: 10.1080/19420862.2025.2563773
Abstract: ABSTRACT Bispecific T cell engager (TCE) therapies have demonstrated transformative clinical success in the treatment of hematological cancers, but the lack of antigens that are sufficiently selective for malignant cells has hampered the success of… read more here.
Keywords: prame pmhc; tumor; cell; geometry ... See more keywords
Fluctuations in T cell receptor and pMHC interactions regulate T cell activation
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DOI: 10.1098/rsif.2021.0589
Abstract: Adaptive immune responses depend on interactions between T cell receptors (TCRs) and peptide major histocompatibility complex (pMHC) ligands located on the surface of T cells and antigen presenting cells (APCs), respectively. As TCRs and pMHCs… read more here.
Keywords: cell; pmhc; cell activation; tcr pmhc ... See more keywords
Initial Viral Inoculum Determines Kinapse-and Synapse-Like T Cell Motility in Reactive Lymph Nodes
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DOI: 10.3389/fimmu.2019.02086
Abstract: T cell activation in lymphoid tissue occurs through interactions with cognate peptide-major histocompatibility complex (pMHC)-presenting dendritic cells (DCs). Intravital imaging studies using ex vivo peptide-pulsed DCs have uncovered that cognate pMHC levels imprint a wide… read more here.
Keywords: synapse like; viral inoculum; motility; inoculum ... See more keywords
Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck
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DOI: 10.3389/fimmu.2021.721722
Abstract: Under physiological conditions, CD8+ T cells need to recognize low numbers of antigenic pMHC class I complexes in the presence of a surplus of non-stimulatory, self pMHC class I on the surface of the APC.… read more here.
Keywords: cd8 cell; cd8; non stimulatory; pmhc ... See more keywords
PANDORA: A Fast, Anchor-Restrained Modelling Protocol for Peptide: MHC Complexes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.878762
Abstract: Deeper understanding of T-cell-mediated adaptive immune responses is important for the design of cancer immunotherapies and antiviral vaccines against pandemic outbreaks. T-cells are activated when they recognize foreign peptides that are presented on the cell… read more here.
Keywords: peptide; pmhc; pmhc complexes; peptide mhc ... See more keywords