MHC Molecules, T cell Receptors, Natural Killer Cell Receptors, and Viral Immunoevasins-Key Elements of Adaptive and Innate Immunity.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9367-9_2
Abstract: Molecules encoded by the Major Histocompatibility Complex (MHC) bind self or foreign peptides and display these at the cell surface for recognition by receptors on T lymphocytes (designated T cell receptors-TCR) or on natural killer… read more here.
Keywords: mhc molecules; natural killer; cell receptors; mhc ... See more keywords
A TCR mechanotransduction signaling loop induces negative selection in the thymus
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DOI: 10.1038/s41590-018-0259-z
Abstract: The T cell antigen receptor (TCR) expressed on thymocytes interacts with self-peptide major histocompatibility complex (pMHC) ligands to signal apoptosis or survival. Here, we found that negative-selection ligands induced thymocytes to exert forces on the… read more here.
Keywords: negative selection; selection; pmhc cd8; pmhc ... See more keywords
Fluctuations in T cell receptor and pMHC interactions regulate T cell activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2021.0589
Abstract: Adaptive immune responses depend on interactions between T cell receptors (TCRs) and peptide major histocompatibility complex (pMHC) ligands located on the surface of T cells and antigen presenting cells (APCs), respectively. As TCRs and pMHCs… read more here.
Keywords: cell; pmhc; cell activation; tcr pmhc ... See more keywords
Initial Viral Inoculum Determines Kinapse-and Synapse-Like T Cell Motility in Reactive Lymph Nodes
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DOI: 10.3389/fimmu.2019.02086
Abstract: T cell activation in lymphoid tissue occurs through interactions with cognate peptide-major histocompatibility complex (pMHC)-presenting dendritic cells (DCs). Intravital imaging studies using ex vivo peptide-pulsed DCs have uncovered that cognate pMHC levels imprint a wide… read more here.
Keywords: synapse like; viral inoculum; motility; inoculum ... See more keywords
Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck
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DOI: 10.3389/fimmu.2021.721722
Abstract: Under physiological conditions, CD8+ T cells need to recognize low numbers of antigenic pMHC class I complexes in the presence of a surplus of non-stimulatory, self pMHC class I on the surface of the APC.… read more here.
Keywords: cd8 cell; cd8; non stimulatory; pmhc ... See more keywords
PANDORA: A Fast, Anchor-Restrained Modelling Protocol for Peptide: MHC Complexes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.878762
Abstract: Deeper understanding of T-cell-mediated adaptive immune responses is important for the design of cancer immunotherapies and antiviral vaccines against pandemic outbreaks. T-cells are activated when they recognize foreign peptides that are presented on the cell… read more here.
Keywords: peptide; pmhc; pmhc complexes; peptide mhc ... See more keywords