A TCR mechanotransduction signaling loop induces negative selection in the thymus
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DOI: 10.1038/s41590-018-0259-z
Abstract: The T cell antigen receptor (TCR) expressed on thymocytes interacts with self-peptide major histocompatibility complex (pMHC) ligands to signal apoptosis or survival. Here, we found that negative-selection ligands induced thymocytes to exert forces on the… read more here.
Keywords: negative selection; selection; pmhc cd8; pmhc ... See more keywords