The short isoform of PML‐RARα activates the NRF2/HO‐1 pathway through a direct interaction with NRF2
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12779
Abstract: The NF‐E2 p45‐related factor 2 (NRF2)–Kelch‐like ECH‐associated protein 1 signaling pathway plays an important role in cytoprotection. In acute promyelocytic leukemia, fusion of the promyelocytic leukemia protein (PML) with retinoic acid receptor alpha (RARα) results… read more here.
Keywords: short isoform; rar; isoform pml; pml rar ... See more keywords
Improving risk‐stratification of natalizumab‐associated PML
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51130
Abstract: Based on publicly available data, we reevaluated current algorithms for stratifying the risk of progressive multifocal leukoencephalopathy (PML) in natalizumab‐treated patients with multiple sclerosis, and found that there are a number of issues. First and… read more here.
Keywords: risk; natalizumab associated; risk stratification; stratification natalizumab ... See more keywords
Serum neurofilaments as candidate biomarkers of natalizumab associated progressive multifocal leukoencephalopathy
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25523
Abstract: We read with great interest the article published by Dalla Costa et al concerning the role of serum neurofilament light chains (NfL) as candidate biomarkers of progressive multifocal leukoencephalopathy (PML) during natalizumab treatment (NTZ-PML) in… read more here.
Keywords: nfl levels; pml onset; serum; serum nfl ... See more keywords
TGF‐β1‐PML SUMOylation‐peptidyl‐prolyl cis–trans isomerase NIMA‐interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27357
Abstract: Transforming growth factor‐β (TGF‐β) signaling pathway is involved in fibrosis in most, if not all forms of cardiac diseases. Here, we evaluate a positive feedback signaling the loop of TGF‐β1/promyelocytic leukemia (PML) SUMOylation/Pin1 promoting the… read more here.
Keywords: positive feedback; fibrosis; tgf; pml ... See more keywords
Single‐center experience on progressive multifocal leukoencephalopathy (PML) cases, neuroimaging relevance, and management at West Virginia University (WVU)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27804
Abstract: Progressive multifocal leukoencephalopathy (PML) is an increasingly common and rapidly fatal demyelinating infection of central nervous system caused by the highly prevalent John Cunningham (JC) virus in immunocompromised individuals belonging to all age groups and… read more here.
Keywords: pml; multifocal leukoencephalopathy; progressive multifocal; leukoencephalopathy pml ... See more keywords
Enhancement of T g of Poly( l ‐lactide) by Incorporation of Biobased Mandelic‐Acid‐Derived Phenyl Groups by Polymerization and Polymer Blending
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular Chemistry and Physics"
DOI: 10.1002/macp.201900392
Abstract: A high-molecular-weight polyester of poly(mandelate-co-lactate) (PML) is prepared by ring-opening polymerization of stereo-configuration controlled cyclic diester monomers of methyl-6-phenyl-1,4-dioxane-2,5-dione (MPDD) and lactide. The attained PML shows excellent glassy properties, although the original stereo-configuration of MPDD… read more here.
Keywords: polymerization; poly lactide; phenyl groups; pml ... See more keywords
Progressive multifocal leukoencephalopathy in patients treated with fumaric acid esters: a review of 19 cases
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurology"
DOI: 10.1007/s00415-017-8509-9
Abstract: Progressive multifocal leukoencephalopathy (PML) is a rare and potentially fatal condition caused by a brain infection with JC polyomavirus (JCV). PML develops almost exclusively in immunocompromised patients and has recently been associated with use of… read more here.
Keywords: fumaric acid; acid esters; progressive multifocal; multifocal leukoencephalopathy ... See more keywords
Clinical and magnetic resonance imaging monitoring in progressive multifocal leukoencephalopathy treated with pembrolizumab: a case report
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04582-4
Abstract: Dear Dr. Federico, T h e d e v e l o pme n t o f p r o g r e s s i v e mu l t i f o c… read more here.
Keywords: resonance imaging; magnetic resonance; pembrolizumab; therapy ... See more keywords
Host-Immune Interactions in JC Virus Reactivation and Development of Progressive Multifocal Leukoencephalopathy (PML)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroimmune Pharmacology"
DOI: 10.1007/s11481-019-09877-8
Abstract: With the advent of immunomodulatory therapies and the HIV epidemic, the impact of JC Virus (JCV) on the public health system has grown significantly due to the increased incidence of Progressive Multifocal Leukoencephalopathy (PML). Currently,… read more here.
Keywords: progressive multifocal; reactivation; multifocal leukoencephalopathy; host ... See more keywords
Acoustic reflection well logging modeling using the frequency-domain finite-element method with a hybrid PML
Sign Up to like & getrecommendations! Published in 2018 at "Applied Geophysics"
DOI: 10.1007/s11770-018-0666-9
Abstract: In this paper, we propose a hybrid PML (H-PML) combining the normal absorption factor of convolutional PML (C-PML) with tangential absorption factor of Mutiaxial PML (M-PML). The H-PML boundary conditions can better suppress the numerical… read more here.
Keywords: pml pml; acoustic reflection; method; hybrid pml ... See more keywords
Early reduction of the splicing factor2/alternative splicing factor: a cellular inhibitor of the JC polyomavirus in natalizumab-treated MS patients long before developing progressive multifocal leukoencephalopathy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of NeuroVirology"
DOI: 10.1007/s13365-019-00793-4
Abstract: Natalizumab is effective against relapsing-remitting multiple sclerosis (MS) but increases the risk of progressive multifocal leukoencephalopathy (PML), which is caused by the activation of the JCV polyomavirus. SF2/ASF (splicing factor2/alternative splicing factor) is a potent… read more here.
Keywords: natalizumab treated; progressive multifocal; multifocal leukoencephalopathy; splicing factor2 ... See more keywords