Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41058-8
Abstract: Many tumors maintain chromosome-ends through a telomerase-independent, DNA-templated mechanism called alternative lengthening of telomeres (ALT). While ALT occurs in only a subset of tumors, it is strongly associated with mutations in the genes ATRX and… read more here.
Keywords: daxx; rapid reversible; atrx daxx; osteosarcoma ... See more keywords
PML Body Component Sp100A Is a Cytosolic Responder to IFN and Activator of Antiviral ISGs
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DOI: 10.1128/mbio.02044-22
Abstract: PML bodies sit at the center stage of various important biological processes; however, the signal transduction networks of these macromolecular protein complexes remain enigmatic. The present study illustrates, in detail and for the first time,… read more here.
Keywords: pml; antiviral isgs; pml body; sp100a ... See more keywords
Establishment of international autoantibody reference standards for the detection of autoantibodies directed against PML bodies, GW bodies, and NuMA protein
Sign Up to like & getrecommendations! Published in 2020 at "Clinical chemistry and laboratory medicine"
DOI: 10.1515/cclm-2020-0981
Abstract: Abstract Objectives Reference materials are important in the standardization of autoantibody testing and only a few are freely available for many known autoantibodies. Our goal was to develop three reference materials for antibodies to PML… read more here.
Keywords: autoantibody; reference materials; gwb ref; ref ... See more keywords
New Evidence of the Importance of Weak Interactions in the Formation of PML-Bodies
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DOI: 10.3390/ijms23031613
Abstract: In this work, we performed a comparative study of the formation of PML bodies by full-length PML isoforms and their C-terminal domains in the presence and absence of endogenous PML. Based on the analysis of… read more here.
Keywords: terminal domains; pml; endogenous pml; formation pml ... See more keywords