Differential Mobility and Self-Association of Arc/Arg3.1 in the Cytoplasm and Nucleus of Living Cells.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00744
Abstract: Arc, also known as Arg3.1, is an activity-dependent immediate-early gene product that plays essential roles in memory consolidation. A pool of Arc is located in the postsynaptic cytoplasm, where it promotes AMPA receptor endocytosis and… read more here.
Keywords: arc; mobility self; differential mobility; cytoplasm ... See more keywords
Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2021.11.30.470516
Abstract: Promyelocytic Leukemia Nuclear Bodies (PML NBs) are nuclear membrane-less organelles physically associated with chromatin underscoring their crucial role in genome function. The H3.3 histone chaperone complex HIRA accumulates in PML NBs upon senescence, viral infection… read more here.
Keywords: pml; hira dynamics; nbs hira; pml nbs ... See more keywords
PML Alternative Splice Products Differentially Regulate HAdV Productive Infection
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00785-22
Abstract: Actual work provides evidence that PML-NB-associated factors might also be beneficial for distinct viral processes indicating why genomes and replication centers of nuclear replicating viruses are often found juxtaposed to PML-NBs. Alternatively spliced PML isoforms… read more here.
Keywords: pml; pml isoforms; replication; infection ... See more keywords
Promyelocytic leukemia nuclear body-like structures can assemble in mouse oocytes
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059130
Abstract: ABSTRACT Promyelocytic leukemia (PML) nuclear bodies (PML-NBs), a class of membrane-less cellular organelles, participate in various biological activities. PML-NBs are known as the core-shell-type nuclear body, harboring ‘client’ proteins in their core. Although multiple membrane-less… read more here.
Keywords: nuclear body; pml nbs; pml; promyelocytic leukemia ... See more keywords
PML nuclear body-residing proteins sequentially associate with HPV genome after infectious nuclear delivery
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007590
Abstract: Subnuclear promyelocytic leukemia (PML) nuclear bodies (NBs) are targeted by many DNA viruses after nuclear delivery. PML protein is essential for formation of PML NBs. Sp100 and Small Ubiquitin-Like Modifier (SUMO) are also permanently residing… read more here.
Keywords: protein; transport; nuclear delivery; hpv ... See more keywords
The Role of Promyelocytic Leukemia Nuclear Bodies During HPV Infection
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.00035
Abstract: Promyelocytic leukemia (PML) nuclear bodies (NBs) are highly dynamic subnuclear structures. Their name giving major component, PML protein, is essential for their formation. PML is present in many different isoforms due to differential splicing, which… read more here.
Keywords: promyelocytic leukemia; nuclear bodies; pml; pml nbs ... See more keywords
Molecular Cloning of Alternative Splicing Variants of the Porcine PML Gene and Its Expression Patterns During Japanese Encephalitis Virus Infection
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2021.757978
Abstract: Promyelocytic leukemia (PML) protein is a crucial component of PML-nuclear bodies (PML-NBs). PML and PML-NBs are involved in the regulation of various cellular functions, including the antiviral immune response. The human PML gene can generate… read more here.
Keywords: pml; porcine pml; infection; pml nbs ... See more keywords