PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45038
Abstract: The promyelocytic leukemia (PML) protein is an essential component of PML nuclear bodies (PML NBs) frequently lost in cancer. PML NBs coordinate chromosomal regions via modification of nuclear proteins that in turn may regulate genes… read more here.
Keywords: pml nuclear; ddit4; expression; mtor ... See more keywords
Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.00049-20
Abstract: PML nuclear bodies (PML-NBs) are implicated in general antiviral defense based on recruiting host restriction factors; however, it is not understood so far why viruses would establish viral replication centers (RCs) juxtaposed to such “antiviral”… read more here.
Keywords: viral replication; replication centers; replication; pml nuclear ... See more keywords
C-terminal motifs in promyelocytic leukemia protein isoforms critically regulate PML nuclear body formation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.202879
Abstract: ABSTRACT Promyelocytic leukemia protein (PML) nuclear bodies (NBs), which are sub-nuclear protein structures, are involved in a variety of important cellular functions. PML-NBs are assembled by PML isoforms, and contact between small ubiquitin-like modifiers (SUMOs)… read more here.
Keywords: protein; promyelocytic leukemia; pml nuclear; formation ... See more keywords
Regulating the p53 Tumor Suppressor Network at PML Biomolecular Condensates
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194549
Abstract: Simple Summary The cell nucleus is organized into different sub-nuclear compartments to control specific cellular processes, including PML nuclear bodies (NBs), also termed PML biomolecular condensates. PML-NBs form multi-protein complexes that are highly responsive to… read more here.
Keywords: tumor suppressor; pml biomolecular; pml nuclear; p53 ... See more keywords