The short isoform of PML‐RARα activates the NRF2/HO‐1 pathway through a direct interaction with NRF2
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12779
Abstract: The NF‐E2 p45‐related factor 2 (NRF2)–Kelch‐like ECH‐associated protein 1 signaling pathway plays an important role in cytoprotection. In acute promyelocytic leukemia, fusion of the promyelocytic leukemia protein (PML) with retinoic acid receptor alpha (RARα) results… read more here.
Keywords: short isoform; rar; isoform pml; pml rar ... See more keywords
Realgar transforming solution-induced differentiation of NB4 cell by the degradation of PML/RARα partially through the ubiquitin-proteasome pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of pharmacal research"
DOI: 10.1007/s12272-019-01170-9
Abstract: PML/retinoic acid receptor alpha (RARα), as a hallmark of acute promyeloid leukemia (APL), is directly related to the outcome of clinical APL remedy. It is reported that arsenicals can effectively degrade PML/RARα, such as arsenic… read more here.
Keywords: rar; degradation; differentiation; pml rar ... See more keywords
TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.04.006
Abstract: Acute promyelocytic leukemia (APL) is driven by the oncoprotein PML-RARα, which antagonizes myeloid differentiation and promotes APL-initiating cell self-renewal. Combined all-trans retinoic acid (ATRA) with arsenic trioxide (As2O3) or chemotherapy dramatically improves the prognosis of… read more here.
Keywords: rar; trib3; promotes apl; oncoprotein pml ... See more keywords
Development and validation of a droplet digital PCR assay for the evaluation of PML-RARα fusion transcripts in acute promyelocytic leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2020.101617
Abstract: Acute promyelocytic leukemia (APL) is an aggressive disease that requires prompt treatment. Promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion genes resulting from reciprocal translocation are considered a molecular basis for diagnosing APL. Moreover, PML-RARα… read more here.
Keywords: pml; promyelocytic leukemia; rar fusion; pml rar ... See more keywords
Deneddylation of PML/RARα reconstructs functional PML nuclear bodies via orchestrating phase separation to eradicate APL.
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00955-8
Abstract: Acute promyelocytic leukemia (APL) is driven by the oncoprotein PML/RARα, which destroys the architecture of PML nuclear bodies (NBs). PML NBs are critical to tumor suppression, and their disruption mediated by PML/RARα accelerates APL pathogenesis.… read more here.
Keywords: phase separation; pml; apl; pml rar ... See more keywords
PML–RARα‐positive cells contribute to scrotal ulceration with all‐trans retinoic acid
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Dermatology"
DOI: 10.1111/ijd.15664
Abstract: ALDEN validation, and there was no coexisting drug needed to dispute, which confirmed the levamisole as the culprit drug in concert with the positive LTT results. We report the Taiwanese pediatric case of TEN induced… read more here.
Keywords: cells contribute; positive cells; pml rar; contribute scrotal ... See more keywords
Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2643-3230.bcd-20-0188
Abstract: The PML/RARα fusion protein is the oncogenic driver in acute promyelocytic leukemia (APL). Although most APL cases are cured by PML/RARα-targeting therapy, relapse and resistance can occur due to drug-resistant mutations. Here we report that… read more here.
Keywords: therapy; fusion; hyperthermia; rar ... See more keywords
Autophagy and Ubiquitin-Mediated Proteolytic Degradation of PML/Rarα Fusion Protein in Matrine-Induced Differentiation Sensitivity Recovery of ATRA-Resistant APL (NB4-LR1) Cells: In Vitro and In Vivo studies
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-115699
Abstract: The major feature that distinguishes acute promyelocytic leukemia (APL) cells from other malignant hematopoietic cells is the expression of promyelocytic leukemia-retinoicacid receptor α (PML-RARα) fusion protein, which contributes to the inhibition of RARα-regulated hematopoietic cellular… read more here.
Keywords: rar; lr1 cells; nb4 lr1; pml rar ... See more keywords
PML Mutation in PML-Rarα Alters PML Nuclear Body Organization and Induces ATRA Resistance in Acute Promyelocytic Leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-118310
Abstract: Acute promyelocytic leukemia (APL) has become a highly curable disease using target drugs including all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) with or without chemotherapy. However, APL patients with acquiredPML mutationsin PML-RARα had dismal… read more here.
Keywords: acute promyelocytic; promyelocytic leukemia; resistance; pml rar ... See more keywords
Unexpected Concomitance of BCR-ABL and PML-Rarα Leukemia - Three-Year Follow-up
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-132259
Abstract: Introduction Acute promyelocytic leukemia (APL) with PML-RARα is a variant type of acute myeloid leukemia (AML), halting granulocytes at the promyelocytic stage1, primarily associated with the t(15;17)(q22;q11-12) translocation2. The fusion gene BCR-ABL1, attributed to the… read more here.
Keywords: cml; bcr abl; pml rar; pml ... See more keywords
A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020005698
Abstract: Transcriptional deregulation initiated by oncogenic fusion proteins plays a vital role in leukemia. The prevailing view is that the oncogenic fusion protein PML/RARα, generated by the chromosome translocation t(15;17), functions as a transcriptional repressor in… read more here.
Keywords: rar; transcriptional deregulation; leukemia; pml rar ... See more keywords